Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Pathology, The Second People's Hospital of Guangdong Province, Guangdong, China.
Pathol Int. 2019 Sep;69(9):519-525. doi: 10.1111/pin.12844. Epub 2019 Aug 1.
Biphasic squamoid alveolar renal cell carcinoma (BSARCC) is a rare and recently characterized form of papillary renal cell carcinoma (PRCC). Herein, we describe three cases of BSARCC that were CD57+. Among a total of 90 cases of PRCC, three cases were found to be consistent with a diagnosis of BSARCC. In addition to reviewing these cases, we reviewed the relevant literature pertaining to this form of cancer and assessed the immunohistochemical staining for CD57 on the available tumor samples. The three BSARCC cases in the present study were composed of two primary populations of cells. Tumors stained positive for CK, PAX8, CK7, CK19, AMACR, EMA, and vimentin. Larger cells expressed detectable levels of cyclin D1, and expression of CD57 was limited to the larger cells. All three patients were alive and free of disease during the most recent follow-up. Our results suggest that the CD57 positivity of at least a subset of cases should necessitate their differentiation from cases of metanephric adenoma.
双向鳞状肺泡肾细胞癌 (BSARCC) 是一种罕见且最近被描述的乳头状肾细胞癌 (PRCC) 形式。本文描述了 3 例 CD57+的 BSARCC 病例。在总共 90 例 PRCC 中，发现 3 例符合 BSARCC 的诊断。除了回顾这些病例，我们还回顾了与这种癌症形式相关的文献，并评估了可用肿瘤样本的 CD57 免疫组织化学染色。本研究中的 3 例 BSARCC 由两种主要细胞群组成。肿瘤表达 CK、PAX8、CK7、CK19、AMACR、EMA 和波形蛋白。较大的细胞表达可检测到的 cyclin D1 水平，而 CD57 的表达仅限于较大的细胞。所有 3 名患者在最近的随访中均存活且无疾病。我们的结果表明，至少一部分病例的 CD57 阳性应使其与后肾腺瘤病例区分开来。
