Seibel Johannes, Amabilino David B, De Feyter Steven
Department of Chemistry, Division of Molecular Imaging and Photonics, KU Leuven-University of Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium.
School of Chemistry & The GSK Carbon Neutral Laboratories for Sustainable Chemistry, The University of Nottingham, Triumph Road, Nottingham, NG7 2TU, UK.
Angew Chem Int Ed Engl. 2019 Sep 9;58(37):12964-12968. doi: 10.1002/anie.201908552. Epub 2019 Aug 21.
Control over polymorph formation in the crystallization of organic molecules remains a huge scientific challenge. Now, preferential formation is presented of one polymorph, formed by chiral molecules, in controlled two-dimensional (2D) nanoconfinement conditions at a liquid-solid interface. So-called nanocorrals to control concomitant polymorph formation were created in situ via a nanoshaving protocol at the interface between 1-phenyloctane and covalently modified highly-oriented pyrolytic graphite (HOPG). The preferentially formed polymorphs, which were less stable in the large-scale monolayers, could be selected simply by varying the orientation of the square nanocorrals with respect to the HOPG lattice.
控制有机分子结晶过程中的多晶型形成仍然是一项巨大的科学挑战。现在，在液固界面的可控二维（2D）纳米限域条件下，由手性分子形成的一种多晶型物实现了优先形成。通过在1-苯基辛烷与共价修饰的高度取向热解石墨（HOPG）之间的界面处采用纳米刮削协议，原位创建了所谓的纳米围栏，以控制伴随的多晶型形成。在大规模单层中稳定性较差的优先形成的多晶型物，可以通过简单地改变方形纳米围栏相对于HOPG晶格的取向来选择。
