Scutt Greg, Allen Marcus, Waxman David
School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK.
Centre for Computational Systems Biology, ISTBI, Fudan University, Shanghai, PR China.
Biosystems. 2019 Oct;184:103996. doi: 10.1016/j.biosystems.2019.103996. Epub 2019 Jul 29.
In this paper we present a mathematical solution that allows the elimination rate-constant or half life of a drug to be estimated from a single blood drug measurement. This is of great utility in clinical areas involving care of criticallly ill or vulnerable patients, where providing more than one blood sample can involve significant risks. The calculations used in our approach, based solely on a single sample, do not require complex pharmacokinetic software, but instead can be simply performed at the patient's bedside using standard personal computing tools. The proposed method allows a personalised estimate of the drug's half life, which is preferable to using population averages, or using estimates based on proxy markers of lagging organ function, which are both indirect and generally inaccurate for a patient with confounding factors.
在本文中，我们提出了一种数学解决方案，可根据单次血液药物测量值估算药物的消除速率常数或半衰期。这在涉及重症或脆弱患者护理的临床领域非常有用，因为采集多份血样可能会带来重大风险。我们的方法所使用的计算仅基于单个样本，不需要复杂的药代动力学软件，而是可以使用标准个人计算工具在患者床边简单地进行。所提出的方法能够对药物半衰期进行个性化估算，这比使用总体平均值或基于滞后器官功能替代标志物的估算更可取，后两者都是间接的，并且对于有混杂因素的患者通常不准确。
