口服皮质类固醇治疗疼痛性急性外耳炎（游泳耳）：一项三盲随机对照试验。
Oral corticosteroids for painful acute otitis externa (swimmer's ear): A triple-blind randomised controlled trial.
机构信息
MBChB, DipObst, FRACGP, General Practitioner, Toogood Road Family Medical Centre, Woree, Qld.
Clare Heal MBChB, DRANZCOG, DipGUMed, FRACGP, MPHTM, PhD, Professor of General Practice, James Cook University, Qld.
出版信息
Aust J Gen Pract. 2019 Aug;48(8):565-572. doi: 10.31128/AJGP-12-18-4795.
BACKGROUND AND OBJECTIVES
Acute otitis externa is often painful. The aim of this study was to evaluate the efficacy of 10 mg oral prednisolone twice daily for four days in addition to conventional therapy.
METHOD
Patients attending general practice clinics in Far North Queensland, Australia, for acute painful otitis externa were given a study capsule with either 10 mg prednisone or placebo.
RESULTS
Seventy-three patients were randomised. Results from 19 patients in the intervention group and 11 patients in the control group were analysed. Oral corticosteroids did not decrease the time to being completely pain-free but decreased the time for pain to reduce from more than 'moderate pain' to less than 'moderate pain', from 3.7 days to 2.4 days (P = 0.012, log rank test).
DISCUSSION
Oral corticosteroids seem to be effective in reducing more than 'moderate pain' to less than 'moderate pain'. However, this result needs to be confirmed in a larger trial.
背景和目的
急性外耳炎常伴有疼痛。本研究旨在评估在常规治疗的基础上加用每日两次、每次 10mg 泼尼松口服治疗 4 天对急性疼痛性外耳炎的疗效。
方法
在澳大利亚北部昆士兰州的普通诊所就诊的急性疼痛性外耳炎患者，随机给予泼尼松 10mg 或安慰剂胶囊。
结果
73 例患者被随机分组。对干预组的 19 例和对照组的 11 例患者进行了分析。口服皮质类固醇并未减少完全无痛的时间，但减少了从“中度疼痛”以上到“中度疼痛”以下的疼痛缓解时间，从 3.7 天缩短至 2.4 天（P=0.012，对数秩检验）。
讨论
口服皮质类固醇似乎能有效缓解“中度疼痛”以上的疼痛，但需要更大规模的试验来证实这一结果。
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