Castellano-Castillo Daniel, Royo José Luis, Martínez-Escribano Ana, Sánchez-Alcoholado Lidia, Molina-Vega María, Queipo-Ortuño María Isabel, Ruiz-Galdon Maximiliano, J Álvarez-Millán Juan, Cabezas-Sanchez Pablo, Reyes-Engel Armando, Tinahones Francisco J, Cardona Fernando, Fernandez-Garcia José C
Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, 29010 Málaga, Spain.
Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición, CIBERobn, 28029 Madrid, Spain.
J Clin Med. 2019 Jul 31;8(8):1136. doi: 10.3390/jcm8081136.
Obesity has been associated with increased risk of presenting hypogonadism. Free testosterone (FT) is the fraction of testosterone that carries out the biological function of testosterone, and is determined from total testosterone (TT) and sex-hormone binding globulin (SHBG) levels. We aimed to study the SHBG polymorphism rs1799941 in a cohort of young non-diabetic obese males to unravel the possible implication of this polymorphism in obesity-related hypogonadism.
212 young (<45 years) non-diabetic obese (BMI ≥ 30 kg/m) males participated in this study. Subjects were classified according to TT and FT levels in: Eugonadal ( 55, TT > 3.5 ng/mL and FT ≥ 70 pg/mL; EuG), normal FT hypogonadism ( 40, TT < 3.5 and FT ≥ 70 pg/mL; normal FT HG) and hypogonadism ( 117, TT < 3.5 ng/mL and TL < 70 pg/mL; HG). The SHBG rs1799941 polymorphism (GG/GA/AA) was analyzed using the Taqman Open Array (Applied biosystem).
The rs1799941 frequencies were different among the groups. Higher proportion of the allele (A) was found in HG, compared to EuG and normal FT HG. Among the genotypes, the rare homozygous (AA) were found in the normal FT HG group and higher levels of serum SHBG and lower of FT were observed. The presence of the allele A was related (according to lineal regression models) to an increased of SHBG levels ((GA) β = 3.28; (AA) β = 12.45) and a decreased of FT levels ((GA) β = -9.19; (AA) β = -18.52). The presence of the allele (A) increased the risk of presenting HG compared to normal FT HG (OR = 2.54).
The rs1799941 of the SHBG gene can partially determine the presence of obesity-related hypogonadism in young non-diabetic males and whether these subjects have normal FT HG.
肥胖与性腺功能减退风险增加有关。游离睾酮（FT）是发挥睾酮生物学功能的部分，由总睾酮（TT）和性激素结合球蛋白（SHBG）水平决定。我们旨在研究年轻非糖尿病肥胖男性队列中的SHBG基因多态性rs1799941，以揭示这种多态性在肥胖相关性腺功能减退中的可能影响。
212名年龄小于45岁的非糖尿病肥胖（BMI≥30kg/m）男性参与了本研究。根据TT和FT水平将受试者分为：性腺功能正常组（55例，TT>3.5ng/mL且FT≥70pg/mL；EuG）、正常FT性腺功能减退组（40例，TT<3.5且FT≥70pg/mL；正常FT HG）和性腺功能减退组（117例，TT<3.5ng/mL且FT<70pg/mL；HG）。使用Taqman Open Array（应用生物系统公司）分析SHBG rs1799941多态性（GG/GA/AA）。
rs1799941频率在各组之间存在差异。与EuG组和正常FT HG组相比，HG组中该等位基因（A）的比例更高。在基因型中，正常FT HG组中发现了罕见的纯合子（AA），且观察到血清SHBG水平较高而FT水平较低。等位基因A的存在（根据线性回归模型）与SHBG水平升高相关（（GA）β=3.28；（AA）β=12.45），与FT水平降低相关（（GA）β=-9.19；（AA）β=-18.52）。与正常FT HG组相比，等位基因（A）的存在增加了发生HG的风险（OR=2.54）。
SHBG基因的rs1799941可部分决定年轻非糖尿病男性中肥胖相关性腺功能减退的存在以及这些受试者是否患有正常FT HG。
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