Cytrynbaum Eric N, MacKay Vincent, Nahman-Lévesque Olivier, Dobbs Matt, Bub Gil, Shrier Alvin, Glass Leon
Department of Mathematics, University of British Columbia, 1984 Mathematics Rd #121, Vancouver, British Columbia V6T 1Z2, Canada.
Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada.
Chaos. 2019 Jul;29(7):073103. doi: 10.1063/1.5092982.
A monolayer of chick embryo cardiac cells grown in an annular geometry supports two simultaneous reentrant excitation waves that circulate as a doublet. We propose a mechanism that can lead to such behavior. The velocity restitution gives the instantaneous velocity of a wave as a function of the time since the passage of the previous wave at a given point in space. Nonmonotonic restitution relationships will lead to situations in which various spacings between circulating waves are possible. In cardiology, the situation in which two waves travel in an anatomically defined circuit is referred to as double-wave reentry. Since double-wave reentry may arise as a consequence of pacing during cardiac arrhythmias, understanding the dynamic features of double-wave reentry may be helpful in understanding the physiological properties of cardiac tissue and in the design of therapy.
生长在环形结构中的单层鸡胚心脏细胞支持两个同时存在的折返性兴奋波，它们以双波形式循环。我们提出了一种能够导致这种行为的机制。速度恢复给出了波在空间中给定位置从前一波通过后随时间变化的瞬时速度。非单调的恢复关系将导致循环波之间出现各种间距的情况。在心脏病学中，两个波在解剖学定义的回路中传播的情况被称为双波折返。由于双波折返可能是心律失常期间起搏的结果，了解双波折返的动态特征可能有助于理解心脏组织的生理特性以及治疗方案的设计。
