Synthesis, anticancer activity, structure-activity relationship and binding mode of interaction studies of substituted pentanoic acids.

Simultaneous inhibition of MMP-2 and HDAC8 may be an effective strategy to target cancer. In continuation of our earlier efforts, a series of substituted pentanoic acids (-) were synthesized and checked for their biological activity along with some earlier reported compounds (). Compounds and were found to induce apoptosis effectively in a dose-dependent fashion in Jurkat-E6.1 cell line. They reduced the expression of both MMP-2 and HDAC8 effectively. also produced prominent intensity of fluorescence to bring nick in Jurkat-E6.1 cells. also showed cellular arrest in sub-G0 phase. Such compounds may be useful to battle against cancer.