Avni-Magen Nili, Zafrir Barak, King Roni, Bdolah-Abram Tali, Shilo-Benjamini Yael
The Tisch Family Zoological Gardens in Jerusalem, Jerusalem, Israel.
Koret School of Veterinary Medicine, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Vet Anaesth Analg. 2019 Sep;46(5):662-666. doi: 10.1016/j.vaa.2019.06.003. Epub 2019 Jun 22.
To establish and compare the effectiveness of two medetomidine-based immobilization protocols in Persian fallow deer (Dama dama mesopotamica).
Prospective, randomized, blinded clinical study.
A group of 31 captive Persian fallow deer.
Deer scheduled for translocation were immobilized with a combination of medetomidine (76 ± 11 μg kg) and ketamine (1.0 ± 0.2 mg kg) (MK; n = 15) or medetomidine (77 ± 11 μg kg) and midazolam (0.10 ± 0.01 mg kg) (MM; n = 16) administered intramuscularly. An observer unaware of group assignments recorded times to immobilization and recovery, monitored physiologic variables and scored the quality of induction, immobilization and recovery (scale 1-5: 1, poor; 5, excellent). Atipamezole was administered for reversal. Data analysis was performed using the t test, the Mann-Whitney U test, the chi-square test and the Fisher's exact test. Significance was set at p < 0.05.
Data are presented as mean ± standard deviation or median (range). Time to induce immobilization was 9 ± 4 and 10 ± 4 minutes in the MK and MM groups, respectively. Immobilization quality score was 5 (1-5) following both combinations. Hemoglobin oxygen saturation (SpO) was significantly lower in the MK (80 ± 8%) than in the MM group (87 ± 8%) although respiratory frequency did not differ between MK and MM (11 ± 5 and 10 ± 2 breaths minute, respectively). Recovery times were 13 ± 6 (MK) and 14 ± 7 minutes (MM) and did not differ between groups. No morbidities or mortalities were recorded during 1 month after immobilization.
The MK and MM combinations produced sufficient immobilization in captive Persian fallow deer for short nonpainful procedures. Based on the SpO values, the MM combination may be associated with less respiratory depression; nevertheless, both combinations may result in a decrease in SpO.
建立并比较两种基于美托咪定的麻醉方案对波斯黇鹿（Dama dama mesopotamica）的有效性。
前瞻性、随机、盲法临床研究。
一组31只圈养的波斯黇鹿。
计划进行转移的鹿通过肌肉注射美托咪定（76±11μg/kg）和氯胺酮（1.0±0.2mg/kg）（MK组；n = 15）或美托咪定（77±11μg/kg）和咪达唑仑（0.10±0.01mg/kg）（MM组；n = 16）进行麻醉。一名不知道分组情况的观察者记录麻醉诱导和苏醒时间，监测生理变量，并对诱导、麻醉和苏醒质量进行评分（1 - 5分：1分，差；5分，优）。使用阿替美唑进行苏醒。数据分析采用t检验、曼-惠特尼U检验、卡方检验和费舍尔精确检验。显著性设定为p < 0.05。
数据以平均值±标准差或中位数（范围）表示。MK组和MM组的麻醉诱导时间分别为9±4分钟和10±4分钟。两种组合后的麻醉质量评分均为5分（1 - 5分）。MK组的血红蛋白氧饱和度（SpO）显著低于MM组（80±8% 对 87±8%），尽管MK组和MM组的呼吸频率无差异（分别为11±5次/分钟和10±2次/分钟）。苏醒时间分别为13±6分钟（MK组）和14±7分钟（MM组），两组之间无差异。麻醉后1个月内未记录到发病或死亡情况。
MK和MM组合在圈养波斯黇鹿中能产生足够的麻醉效果，适用于短期无痛操作。基于SpO值，MM组合可能与较少的呼吸抑制相关；然而，两种组合都可能导致SpO降低。
