载脂蛋白E e4等位基因与阿尔茨海默病的锥体外系症状相关。
Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer's disease.
作者信息
Chang Yang-Pei, Chou Mei-Chuan, Lai Chiou-Lian, Chien I, Yang Yuan-Han
机构信息
Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
出版信息
Neuropsychiatr Dis Treat. 2019 Jul 9;15:1915-1919. doi: 10.2147/NDT.S207050. eCollection 2019.
BACKGROUND
Extrapyramidal symptoms (EPS) are not uncommon in Alzheimer's disease (AD). As apolipoprotein E(APOE) e4 allele is a major risk factor for late-onset AD, we intend to examine the association between APOE genotype and the development of EPS in AD.
METHOD
This study describes two hundred and fifty-five clinically diagnosed AD patients aged 72 to 80 years from 2010 to 2014. We reviewed the medical charts to determine the development of EPS. APOE genotypes were also confirmed.
RESULTS
APOE e4 allele was detected in 74 patients (29%) and rigidity was among the most common EPS (61%). After adjusting the age, gender, baseline clinical dementia rating, we found AD patients carrying APOE e4 allele are more likely to develop EPS (OR: 4.515, =0.033).
CONCLUSION
This study demonstrates the higher coexistence of EPS in AD patients with APOE e4 allele. Furthermore, the identification of APOE e4 allele in the development of EPS in AD patients supports the hypothesis that EPS may be partially attributed to AD pathology.
背景
锥体外系症状（EPS）在阿尔茨海默病（AD）中并不罕见。由于载脂蛋白E（APOE）ε4等位基因是晚发型AD的主要危险因素，我们旨在研究APOE基因型与AD患者EPS发生之间的关联。
方法
本研究描述了2010年至2014年间255例年龄在72至80岁之间临床诊断为AD的患者。我们查阅病历以确定EPS的发生情况。同时也确认了APOE基因型。
结果
74例患者（29%）检测到APOE ε4等位基因，强直是最常见的EPS之一（61%）。在调整年龄、性别、基线临床痴呆评定量表后，我们发现携带APOE ε4等位基因的AD患者更易发生EPS（比值比：4.515，P = 0.033）。
结论
本研究表明携带APOE ε4等位基因的AD患者中EPS共存情况更常见。此外，在AD患者EPS发生过程中APOE ε4等位基因的发现支持了EPS可能部分归因于AD病理的假说。
Zotero 插件