首次心肌梗死后头六个月内的心率变异性与抑郁症发病率
Heart rate variability and incidence of depression during the first six months following first myocardial infarction.
作者信息
Wilkowska Alina, Rynkiewicz Andrzej, Wdowczyk Joanna, Landowski Jerzy, Cubała Wiesław Jerzy
机构信息
Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdańsk, Poland.
Department of Cardiology and Cardiosurgery, Faculty of Medicine, University of Warmia and Mazury, Olsztyn, Poland.
出版信息
Neuropsychiatr Dis Treat. 2019 Jul 10;15:1951-1956. doi: 10.2147/NDT.S212528. eCollection 2019.
BACKGROUND
Post-myocardial depression is a highly prevalent condition worsening the course and prognosis of coronary artery disease. One of the possible pathogenetic factors is dysregulation of the autonomous nervous system, resulting in heart rate variability reduction.
METHODS
Twenty two patients hospitalised due to a first myocardial infarction were included. The Beck Depression Inventory (BDI) was used to rate the severity of their depressive symptoms.
RESULTS
Depressive symptomatology, defined as BDI ≥10, was present in 36.3% of the patients. Increase in heart rate variability (HRV) was observed in both groups during the first 6 months after the myocardial infarction. The HRV was significantly lower in the depressed group compared to patients without depression.
CONCLUSION
Presence of depression after the myocardial infarction (MI) is associated with a significant decrease of the time domain HRV measure SDNN (standard deviation of all normal RR intervals) and with its slower increase during at least a three months period.
背景
心肌梗死后抑郁是一种非常普遍的病症，会使冠状动脉疾病的病程和预后恶化。可能的致病因素之一是自主神经系统失调，导致心率变异性降低。
方法
纳入22例因首次心肌梗死住院的患者。使用贝克抑郁量表（BDI）对其抑郁症状的严重程度进行评分。
结果
抑郁症状（定义为BDI≥10）在36.3%的患者中存在。两组在心肌梗死后的前6个月均观察到心率变异性（HRV）增加。与无抑郁的患者相比，抑郁组的HRV显著更低。
结论
心肌梗死后出现抑郁与时域HRV测量指标SDNN（所有正常RR间期的标准差）显著降低以及在至少三个月的时间内其升高缓慢有关。
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