小鼠腹腔巨噬细胞诱导持续的I-A表达：与Bcgr和Bcgs小鼠的T细胞反应缺乏相关性。
Induction of continuous I-A expression by murine peritoneal macrophages: lack of correlation with T cell responses of Bcgr and Bcgs mice.
作者信息
Kwasniewski M N, Zwilling B S
机构信息
Department of Microbiology, College of Biological Sciences, Ohio State University, Columbus 43210.
出版信息
J Leukoc Biol. 1988 Sep;44(3):192-7. doi: 10.1002/jlb.44.3.192.
The induction of continuous I-A expression by L3T4 and Lyt2 lymphocyte subpopulations from Bcgr and Bcgs mice was compared. We found that the induction of continuous I-A expression was independent of the Bcg genotype of the T cells. T cells from congenic Bcgs BALB/c mice and C.D2Bcgr mice could not induce continuous I-A expression in vitro and were deficient in their ability to produce IFN-gamma in vitro. In contrast, T cells from other strains of Bcgr and Bcgs mice could induce continuous I-A expression. Both recombinant IL-2 and IL-4 acted synergistically with low levels of IFN-gamma to induce continuous I-A expression by macrophages from Bcgr mice.
比较了来自Bcgr和Bcgs小鼠的L3T4和Lyt2淋巴细胞亚群对持续I-A表达的诱导作用。我们发现持续I-A表达的诱导与T细胞的Bcg基因型无关。同基因Bcgs BALB/c小鼠和C.D2Bcgr小鼠的T细胞在体外不能诱导持续I-A表达，且体外产生IFN-γ的能力不足。相比之下，来自其他Bcgr和Bcgs小鼠品系的T细胞可以诱导持续I-A表达。重组IL-2和IL-4均与低水平的IFN-γ协同作用，诱导Bcgr小鼠巨噬细胞持续表达I-A。
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