周质鞭毛的结构与组装。
Architecture and Assembly of Periplasmic Flagellum.
机构信息
Microbial Sciences Institute University, West Haven, CT 06516.
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536.
出版信息
Microbiol Spectr. 2019 Jul;7(4). doi: 10.1128/microbiolspec.PSIB-0030-2019.
Abstract
Periplasmic flagella are complex nanomachines responsible for distinctive morphology and motility of spirochetes. Although bacterial flagella have been extensively studied for several decades in the model systems and , our understanding of periplasmic flagella in many disease-causing spirochetes remains incomplete. Recent advances, including molecular genetics, biochemistry, structural biology, and cryo-electron tomography, have greatly increased our understanding of structure and function of periplasmic flagella. In this chapter, we summarize some of the recent findings that provide new insights into the structure, assembly, and function of periplasmic flagella.
摘要
周质鞭毛是复杂的纳米机器，负责螺旋体独特的形态和运动性。尽管在模型系统[细菌名称]和[细菌名称]中，细菌鞭毛已经被广泛研究了几十年，但我们对许多致病螺旋体中的周质鞭毛的理解仍然不完整。最近的进展，包括分子遗传学、生物化学、结构生物学和低温电子断层扫描，极大地提高了我们对周质鞭毛结构和功能的理解。在本章中，我们总结了一些最近的发现，这些发现为周质鞭毛的结构、组装和功能提供了新的见解。
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