Skripkina E, Canivet A, Wautier M, Martiny D, Hallin M, Meex C, Layios N
Service d'Anesthésie-Réanimation, CHU Liège, Belgique.
Service de Cardiologie et des Soins Intensifs, CHC Liège, Belgique.
Rev Med Liege. 2019 Jul;74(7-8):420-423.
Cases of Campylobacter jejuni meningitis are extremely rare. In the literature, less than ten cases have been described so far, although Campylobacter spp is one of the most common pathogens causing gastroenteritis in the world. Some common stigmata can be found across these cases such as rupture of the blood-brain barrier, immunosuppression, as well as the tropism of Camplylobacter jejuni for neurological parenchyma. Campylobacter jejuni bacteremia is certainly underestimated because Campylobacter is a thermophilic bacterium and special conditions are required to isolate this organism in blood cultures. PCR is thus an interesting alternative technique for diagnosis. In our case, a patient with a history of resected astrocytoma, had undergone treatment with chemotherapy and radiotherapy because of anaplastic transformation. The patient was admitted with gastroenteritis and Campylobacter jejuni meningitis. The diagnosis was obtained initially on stool cultures and then by PCR of cerebrospinal fluid. The evolution was favorable with meropenem.
空肠弯曲菌脑膜炎病例极为罕见。在文献中,迄今为止报道的病例不到十例,尽管弯曲菌属是世界上引起肠胃炎最常见的病原体之一。在这些病例中可以发现一些常见特征,如血脑屏障破裂、免疫抑制以及空肠弯曲菌对神经实质的嗜性。空肠弯曲菌菌血症肯定被低估了,因为弯曲菌是嗜热菌,在血培养中分离这种微生物需要特殊条件。因此,聚合酶链反应(PCR)是一种有趣的诊断替代技术。在我们的病例中,一名有星形细胞瘤切除病史的患者,因间变性转化接受了化疗和放疗。该患者因肠胃炎和空肠弯曲菌脑膜炎入院。最初通过粪便培养诊断,然后通过脑脊液PCR确诊。使用美罗培南治疗后病情好转。