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肾移植后并发噬血细胞综合征的播散性弓形虫病:一例报告及文献复习

Disseminated toxoplasmosis associated with hemophagocytic syndrome after kidney transplantation: A case report and review.

作者信息

Gay Juliette, Gendron Nicolas, Verney Charles, Joste Valentin, Dardé Marie-Laure, Loheac Charlotte, Vrtovsnik François, Argy Nicolas, Houze Sandrine

机构信息

Parasitology and mycology laboratory, Bichat-Claude Bernard Hospital, APHP, Paris, France.

Faculty of Pharmacy, Paris Descartes University, Sorbonne Paris Cité, Paris, France.

出版信息

Transpl Infect Dis. 2019 Oct;21(5):e13154. doi: 10.1111/tid.13154. Epub 2019 Aug 23.

DOI:10.1111/tid.13154
PMID:31373746
Abstract

Disseminated toxoplasmosis is infrequent after kidney transplant transmission but life-threatening because of a lack of diagnostic suspicion as well as specific chemoprophylaxis recommendations. Solid organ transplantation has resulted in few cases of disseminated toxoplasmosis presenting with associated hemophagocytic syndrome. Herein, we report, within the context of a donor/receiver mismatch, a case of a toxoplasmosis associated with hemophagocytic syndrome in a kidney transplant recipient. Molecular and serological investigations confirmed Toxoplasma gondii transmission through the kidney graft.

摘要

肾移植传播后播散性弓形虫病并不常见,但由于缺乏诊断怀疑以及特定的化学预防建议,它会危及生命。实体器官移植导致出现播散性弓形虫病并伴有噬血细胞综合征的病例很少。在此,我们报告在供体/受体不匹配的情况下,一名肾移植受者发生与噬血细胞综合征相关的弓形虫病病例。分子和血清学调查证实弓形虫通过肾移植传播。

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