Perret G, Valensi P, Hugues J N, Vassy R, Uzzan B
University of North Paris, Medical School, Bobigny, France.
Methods Find Exp Clin Pharmacol. 1988 Jun;10(6):387-91.
On the basis of a pharmacokinetic model using the data of a TRH test and without the use of radio-isotope tracers, a simple procedure of estimation of PRL and TSH TRH-stimulated release and elimination half-lives is presented. TRH tests were performed in 33 healthy subjects and their data were used to calculate the kinetic parameters of each subject. Elimination half-lives of TSH and PRL were found to be respectively (mean +/- SD in min) 63 +/- 7.4 and 35 +/- 2.8. Release half-lives were 8.2 +/- 1.3 for TSH and 5 +/- 0.4 for PRL. The usefulness of the procedure in the evaluation of drug effects on pituitary secretion in man and the comparison with the literature data are discussed.
基于使用促甲状腺激素释放激素（TRH）试验数据且不使用放射性同位素示踪剂的药代动力学模型，提出了一种估算TRH刺激的催乳素（PRL）和促甲状腺激素（TSH）释放及消除半衰期的简单方法。对33名健康受试者进行了TRH试验，并利用他们的数据计算了每个受试者的动力学参数。发现TSH和PRL的消除半衰期分别为（以分钟计，均值±标准差）63±7.4和35±2.8。TSH的释放半衰期为8.2±1.3，PRL的释放半衰期为5±0.4。讨论了该方法在评估药物对人体垂体分泌影响方面的实用性以及与文献数据的比较。
