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早产儿的产前感染与脑室内出血：一项荟萃分析。

Antenatal infection and intraventricular hemorrhage in preterm infants: A meta-analysis.

作者信息

Huang Jinglan, Meng Junjie, Choonara Imti, Xiong Tao, Wang Yibin, Wang Huiqing, Qu Yi, Mu Dezhi

机构信息

Department of Pediatrics, West China Second University Hospital.

Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, Sichuan University, Chengdu, Sichuan, China.

出版信息

Medicine (Baltimore). 2019 Aug;98(31):e16665. doi: 10.1097/MD.0000000000016665.

DOI:10.1097/MD.0000000000016665
PMID:31374040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6709165/
Abstract

BACKGROUND

The aim of this study was to summarize current evidence evaluating the association between antenatal infection and intraventricular hemorrhage (IVH) in preterm infants.

MATERIALS AND METHODS

We searched for published articles on antenatal infection and IVH in 3 English (PubMed, the Cochrane Library, and EBSCO) and 3 Chinese (VEIPU, CNKI, and WANFANG) databases on May 19, 2019. In addition, the references of these articles were screened. The included studies had to meet all of the following criteria: preterm infants (<37 weeks); comparing antenatal infection with no infection; the outcomes included IVH (all grades), mild IVH, or sereve IVH; the type of study was randomized controlled trial or cohort study.

RESULTS

A total of 23 cohort studies involving 13,605 preterm infants met our inclusion criteria. Antenatal infection increased the risk of IVH (odds ratios ([OR] 2.18, 95% confidence intervals [CI] 1.58-2.99), mild IVH (OR 1.95, 95% CI 1.09-3.49) and severe IVH (OR 2.65, 95% CI 1.52-4.61). For type of antenatal infection, the ORs and 95% CI were as follows: 2.21 (1.60-3.05) for chorioamnionitis, 2.26 (1.55-3.28) for histologic chorioamnionitis, 1.88 (1.22-2.92) for clinical chorioamnionitis, and 1.88 (1.14-3.10) for ureaplasma.

CONCLUSIONS

Antenatal infection may increase the risk of developing IVH in the preterm infant. The evidence base is however of low quality and well-designed studies are needed.

摘要

背景

本研究旨在总结当前评估产前感染与早产儿脑室内出血（IVH）之间关联的证据。

材料与方法

2019年5月19日，我们在3个英文数据库（PubMed、Cochrane图书馆和EBSCO）和3个中文数据库（维普、知网和万方）中检索了关于产前感染和IVH的已发表文章。此外，还筛选了这些文章的参考文献。纳入的研究必须符合以下所有标准：早产儿（<37周）；比较产前感染与未感染；结局包括IVH（所有级别）、轻度IVH或重度IVH；研究类型为随机对照试验或队列研究。

结果

共有23项涉及13,605名早产儿的队列研究符合我们的纳入标准。产前感染增加了IVH的风险（比值比[OR] 2.18，95%置信区间[CI] 1.58 - 2.99）、轻度IVH（OR 1.95，95% CI 1.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6caf/6709165/77dc56e1f815/medi-98-e16665-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6caf/6709165/d0cfbe3822d5/medi-98-e16665-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6caf/6709165/8db165d5387a/medi-98-e16665-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6caf/6709165/50980317175b/medi-98-e16665-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6caf/6709165/0fc8c25576ae/medi-98-e16665-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6caf/6709165/77dc56e1f815/medi-98-e16665-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6caf/6709165/d0cfbe3822d5/medi-98-e16665-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6caf/6709165/8db165d5387a/medi-98-e16665-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6caf/6709165/50980317175b/medi-98-e16665-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6caf/6709165/0fc8c25576ae/medi-98-e16665-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6caf/6709165/77dc56e1f815/medi-98-e16665-g007.jpg

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