Shephard R A
Department of Psychology, University of Ulster, Jordanstown, N Ireland.
Life Sci. 1988;43(11):897-904. doi: 10.1016/0024-3205(88)90265-2.
The effects of sodium valproate (100 and 300 mg/kg) on fluid consumption in water deprived rats were assessed. Drinking was inhibited to approximately equal extents by a water pre-load, by d-amphetamine (1.5 mg/kg), by neophobia and by shock at mild (0.3mA) or moderate (0.5mA) intensities, the latter condition having an enhanced level of deprivation also. At both doses valproate significantly enhanced drinking in the neophobia, mild shock and moderate shock conditions but failed to increase drinking suppressed by pre-load or d-amphetamine. It is concluded that the increases in drinking suppressed by neophobia or shock which valproate induces are due to anxiolytic actions of the drug and not non-specific enhancement of fluid consumption. The present results also constitute a further parallel between the actions of valproate and those of benzodiazepines.
评估了丙戊酸钠（100和300毫克/千克）对禁水大鼠饮水行为的影响。水预负荷、右旋苯丙胺（1.5毫克/千克）、新物恐惧症以及轻度（0.3毫安）或中度（0.5毫安）强度的电击均能在大致相同程度上抑制饮水，后一种情况还伴有更高水平的缺水。在两种剂量下，丙戊酸钠均能显著增加新物恐惧症、轻度电击和中度电击条件下的饮水量，但未能增加由水预负荷或右旋苯丙胺抑制的饮水量。得出的结论是，丙戊酸钠诱导的新物恐惧症或电击抑制的饮水量增加是由于该药物的抗焦虑作用，而非对液体消耗的非特异性增强。目前的结果也进一步证明了丙戊酸钠与苯二氮䓬类药物作用之间的相似性。
