交通事故后创伤后应激障碍的异常局部一致性：一项静息态功能磁共振成像研究。
Aberrant regional homogeneity in post-traumatic stress disorder after traffic accident: A resting-state functional MRI study.
机构信息
The Second School of Clinical Medicine, Southern Medical University, People's Republic of China.
The Department of Medical Imaging Guangdong Second Provincial General Hospital, Southern Medical University, People's Republic of China.
出版信息
Neuroimage Clin. 2019;24:101951. doi: 10.1016/j.nicl.2019.101951. Epub 2019 Jul 22.
OBJECTIVES
The present study explored the changes in spontaneous regional activity in post-traumatic stress disorder (PTSD) patients, who experienced severe traffic accidents.
METHODS
20 drug-naive PTSD patients and 18 healthy control subjects were imaged using resting-state functional magnetic resonance imaging (rs-fMRI) and analyzed by the algorithm of regional homogeneity (ReHo).
RESULTS
Compared to the healthy control group, the PTSD group showed decreased ReHo values in the right angular gyrus. In addition, a negative correlation was found between the activity level of the angular gyrus and the CAPS score.
CONCLUSION
The dysfunctions were found in the memory- and emotion-related areas, suggested a possible mechanism of memory dysregulation that might be related to the intrusive memory symptoms of PTSD. These results provided imaging evidence that might provide an in-depth understanding of the intrinsic functional architecture of PTSD.
目的
本研究探讨了经历严重交通事故后创伤后应激障碍（PTSD）患者自发区域活动的变化。
方法
使用静息态功能磁共振成像（rs-fMRI）对 20 名未用药的 PTSD 患者和 18 名健康对照者进行成像，并通过局部一致性（ReHo）算法进行分析。
结果
与健康对照组相比，PTSD 组右侧角回的 ReHo 值降低。此外，角回的活动水平与 CAPS 评分呈负相关。
结论
在与记忆和情绪相关的区域发现了功能障碍，提示记忆调节可能存在异常，这可能与 PTSD 的闯入性记忆症状有关。这些结果提供了影像学证据，可能为深入了解 PTSD 的内在功能结构提供了依据。
Zotero 插件