自身免疫中滤泡辅助 T 细胞的空间和功能异质性。
Spatial and functional heterogeneity of follicular helper T cells in autoimmunity.
机构信息
Department of Internal Medicine, Section of Rheumatology, New Haven, CT, United States.
Department of Internal Medicine, Section of Rheumatology, New Haven, CT, United States; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, United States.
出版信息
Curr Opin Immunol. 2019 Dec;61:1-9. doi: 10.1016/j.coi.2019.06.005. Epub 2019 Jul 30.
Abstract
Follicular helper T cells provide signals that promote B cell development, proliferation, and production of affinity matured and appropriately isotype switched antibodies. In addition to their classical locations within B cell follicles and germinal centers therein, B cell helper T cells are also found in extrafollicular spaces - either in secondary lymphoid or non-lymphoid tissues. Both follicular and extrafollicular T helper cells drive autoantibody-mediated autoimmunity. Interfering with B cell help provided by T cells can ameliorate autoimmune disease in animal models and human patients. The next frontier in Tfh cell biology will be identification of Tfh cell-specific pathogenic changes in autoimmunity and exploiting them for therapeutic purposes.
摘要
滤泡辅助 T 细胞提供信号，促进 B 细胞的发育、增殖以及亲和力成熟和适当同种型转换的抗体的产生。除了在 B 细胞滤泡和其中的生发中心的经典位置之外，B 细胞辅助 T 细胞也存在于滤泡外空间——在次级淋巴组织或非淋巴组织中。滤泡和滤泡外辅助 T 细胞都驱动自身抗体介导的自身免疫。干扰 T 细胞提供的 B 细胞辅助可以改善动物模型和人类患者的自身免疫性疾病。Tfh 细胞生物学的下一个前沿将是鉴定自身免疫中的 Tfh 细胞特异性致病性变化，并将其用于治疗目的。
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