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心脏移植中获取途径与机构风险承受能力的差异:一项全国性开放队列研究。

Discrepancies in access and institutional risk tolerance in heart transplantation: A national open cohort study.

作者信息

Suarez-Pierre Alejandro, Lui Cecillia, Zhou Xun, Fraser Charles D, Crawford Todd C, Choi Chun W, Whitman Glenn J, Higgins Robert S, Kilic Ahmet

机构信息

Department of Surgery, Division of Cardiac Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

出版信息

J Card Surg. 2019 Oct;34(10):994-1003. doi: 10.1111/jocs.14179. Epub 2019 Aug 2.

Abstract

BACKGROUND

The impact of center volume on heart transplantation is widely recognized and serves as a benchmark for certification and reimbursement.

STUDY AIMS

Study sociodemographic variables associated with access to high-volume centers and substantiate the importance of extending access to underserved populations.

METHODS

This study focused on adults undergoing heart transplantation between 2006 and 2015. Centers were clustered into terciles (>25, 14-25, or <14 transplants per year) and factors associated with receiving care in different terciles were identified through multinomial regression.

RESULTS

During the study period, 18 725 patients were transplanted at 145 centers. Younger age (<30 years) (P = .005), lower educational level (P < .001), and government-based insurance (P < .001) were associated to lower odds of receiving care at a high-volume center. These centers had higher risk recipients and accepted organs from higher risk donors, when compared to intermediate- and low-volume centers. Receiving care at high (odds ratio [OR], 1.212; P = .017) and intermediate-volume centers (OR, 1.304; P = .001) was associated with greater odds of 1-year survival when compared with low-volume centers.

CONCLUSION

Social, demographic, and geographic factors affect access to high- and intermediate-volume centers. High-volume centers tolerate more risk while providing excellent survival. Awareness of this impact should prompt an extension of access to care for underserved patient populations.

摘要

背景

心脏移植中心的手术量对心脏移植的影响已得到广泛认可,并作为认证和报销的基准。

研究目的

研究与进入高手术量中心相关的社会人口统计学变量,并证实扩大服务不足人群获得医疗服务机会的重要性。

方法

本研究聚焦于2006年至2015年间接受心脏移植的成年人。将中心分为三个等级(每年>25例、14 - 25例或<14例移植手术),并通过多项回归分析确定与在不同等级中心接受治疗相关的因素。

结果

在研究期间,145个中心共为18725名患者进行了移植手术。年龄较小(<30岁)(P = 0.005)、教育水平较低(P < 0.001)以及政府医保(P < 0.001)与在高手术量中心接受治疗的几率较低相关。与中等手术量和低手术量中心相比,这些中心接收的受者风险更高,接受的供体器官风险也更高。与低手术量中心相比,在高手术量中心(比值比[OR],1.212;P = 0.017)和中等手术量中心(OR,1.304;P = 0.001)接受治疗的患者1年生存率更高。

结论

社会、人口统计学和地理因素影响进入高手术量和中等手术量中心的机会。高手术量中心在提供出色生存率的同时能承受更多风险。认识到这种影响应促使扩大服务不足患者群体获得医疗服务的机会。

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