用丙炔苯丙胺（司来吉兰）治疗两周并不会延长帕金森病患者的左旋多巴疗效：一项双盲交叉安慰剂对照试验。
Two weeks of treatment with deprenyl (selegiline) does not prolong L-dopa effect in parkinsonian patients: a double-blind cross-over placebo-controlled trial.
作者信息
Rascol O, Montastruc J L, Senard J M, Demonet J F, Simonetta M, Rascol A
机构信息
Service de Pharmacologie Médicale et Clinique, INSERM U 317, Faculté de Médecine, Toulouse, France.
出版信息
Neurology. 1988 Sep;38(9):1387-91. doi: 10.1212/wnl.38.9.1387.
We investigated the influence of 2 weeks of treatment with deprenyl on the acute effect of a single dose of 200 mg of L-dopa in a double-blind cross-over placebo-controlled trial in 16 parkinsonian patients with wearing-off phenomena. Deprenyl induced no significant benefit in the duration or the maximal improvement of L-dopa's effect. Moreover, deprenyl treatment did not improve the patient's motor status.
在一项针对16名有剂末现象的帕金森病患者的双盲交叉安慰剂对照试验中，我们研究了用司来吉兰治疗2周对单剂量200毫克左旋多巴急性效应的影响。司来吉兰在左旋多巴效应的持续时间或最大改善方面未产生显著益处。此外，司来吉兰治疗并未改善患者的运动状态。
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