Willoughby J, Glover V, Sandler M, Albanese A, Jenner P, Marsden C D
Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Hospital, London, U.K.
Neurosci Lett. 1988 Jul 19;90(1-2):100-6. doi: 10.1016/0304-3940(88)90794-x.
This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.
本研究描述了狨猴脑中单胺氧化酶（MAO）的组织化学定位。未观察到MAO A染色，但在许多区域发现了MAO B，其中黑质染色强度中等，纹状体和伏隔核等区域染色强度高。与大鼠相比，黑质纹状体通路中的高活性可能部分解释了狨猴对MPTP毒性更敏感的原因。与大鼠一样，中缝核中存在高活性。然而，与大鼠不同的是，在血管或脑室衬里中未观察到MAO B的富集。
