Coiacetto F, Arthur I, Sullivan L, Leung M
Department of Veterinary Pathology, School of Veterinary Medicine, Murdoch University, Murdoch, Australia.
Department of Microbiology, PathWest Laboratory Medicine, QE2 Medical Centre, Nedlands, Australia.
J Comp Pathol. 2019 Jul;170:74-77. doi: 10.1016/j.jcpa.2019.06.001. Epub 2019 Jul 9.
A male bilby (Macrotis lagotis) was presented to the Murdoch University Veterinary Anatomical Pathology Service following humane destruction due to severe lethargy. The bilby was emaciated with a focal ulcerated skin lesion on the dorsal tail base. Multifocal to coalescing foci of pyogranulomatous and often necrotizing inflammation was present within multiple organs, including the tail wound, adrenal glands, kidneys, lungs, brain, testes, lymph nodes, heart, liver, spleen and salivary glands. Admixed were abundant intrahistiocytic and extracellular pleomorphic yeast (round, oval and cigar-shaped) up to 6 μm diameter, often with a thin clear halo and occasional narrow-based budding. The diagnosis of disseminated sporotrichosis was confirmed via culture and sequencing of the internal transcribed spacer region of the causative agent, Sporothrix schenckii sensu lato. The route of entry of infection was considered most likely to have been via cutaneous inoculation of the tail base wound. To the authors' knowledge, this report describes the first known case of sporotrichosis in a native Australian animal.
一只雄性兔耳袋狸（Macrotis lagotis）因严重嗜睡被人道毁灭后，被送至默多克大学兽医解剖病理学服务中心。该兔耳袋狸消瘦，尾基部背侧有一处局部溃疡性皮肤病变。多个器官内存在多灶性至融合性的脓性肉芽肿性且常为坏死性炎症灶，包括尾部伤口、肾上腺、肾脏、肺、脑、睾丸、淋巴结、心脏、肝脏、脾脏和唾液腺。组织细胞内和细胞外有大量直径达6μm的多形性酵母（圆形、椭圆形和雪茄形），常有薄的透明晕，偶尔有窄基芽生。通过对病原体申克孢子丝菌复合群（Sporothrix schenckii sensu lato）的内部转录间隔区进行培养和测序，确诊为播散性孢子丝菌病。感染的进入途径最有可能是通过尾部基部伤口的皮肤接种。据作者所知，本报告描述了澳大利亚本土动物中首例已知的孢子丝菌病病例。
