Laboratory of Research and Development of Analytical Solutions (LIDSA), Department of Analytical Chemistry, Nutrition and Food Science, Faculty of Chemistry, University of Santiago de Compostela, E-15782, Santiago de Compostela, Spain.
Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE), Faculty of Engineering, University of Porto, 4200-465, Porto, Portugal.
J Chromatogr A. 2019 Dec 6;1607:460398. doi: 10.1016/j.chroma.2019.460398. Epub 2019 Jul 24.
A methodology based on solid-phase microextraction (SPME) followed by gas chromatography-tandem mass spectrometry (GC-MS/MS) was developed for the simultaneous analysis of different families of personal care products (PCPs) including fragrance allergens, synthetic musks, phthalates, antioxidants and UV filters in continental waters. The main parameters affecting SPME procedure were optimized by an ANOVA study. The final selected conditions comprised the use of 10 mL of sample with 20% (w/v) of sodium chloride (NaCl), polydimtehylsiloxane/divinylbenzene (PDMS/DVB) fiber and 20 min of extraction time at 100 °C in the head-space mode. Good linearity (R>0.9925), quantitative recoveries (>79%), and precision (RSD < 15%) were achieved for all compounds under the optimal conditions. Limits of quantification (LOQs) at the sub and low ng L were obtained. The validated methodology was successfully applied to the analysis of river water samples from the North Portuguese coast allowing the determination of five different families of PCPs, including a total of 43 compounds in a single chromatographic run within 23 min.
建立了一种基于固相微萃取（SPME）结合气相色谱-串联质谱（GC-MS/MS）的方法，用于同时分析不同种类的个人护理产品（PCPs），包括大陆水中的香料过敏原、合成麝香、邻苯二甲酸酯、抗氧化剂和紫外线滤光剂。通过方差分析研究优化了影响 SPME 过程的主要参数。最终选择的条件包括使用 10 mL 含 20%（w/v）氯化钠（NaCl）的样品，使用聚二甲基硅氧烷/二乙烯基苯（PDMS/DVB）纤维，在顶空模式下于 100°C 下萃取 20 分钟。在最佳条件下，所有化合物均获得了良好的线性（R>0.9925）、定量回收率（>79%）和精密度（RSD<15%）。在亚和低 ng L 水平下获得了定量限（LOQs）。该经验证的方法成功应用于葡萄牙北部海岸河流水样的分析，允许在单个色谱运行中同时测定 5 种不同种类的 PCPs，总共可在 23 分钟内测定 43 种化合物。
