基于 Gd 标记的碳点用于磁共振成像中肿瘤血管通透性的精确评估
Gd-encapsulated carbonaceous dots for accurate characterization of tumor vessel permeability in magnetic resonance imaging.
机构信息
Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, China; TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Department of Chemistry and Bio-Imaging Research Center, The University of Georgia Athens, GA, USA.
出版信息
Nanomedicine. 2019 Oct;21:102074. doi: 10.1016/j.nano.2019.102074. Epub 2019 Jul 31.
The assessment of vascular permeability of malignant tumor plays an important role in the diagnosis and treatment of cancer. Dynamic contrast-enhanced magnetic resonance image (DCE-MRI) using Gd-encapsulated carbonaceous dots and Gd-DTPA-BMA as contrast agents was performed in 4T1 mouse breast cancer and HCC827 human non-small-cell lung cancer (NSNLC) xenograft models. Histopathological parameters of tumor vascularity microvessel density (MVD), microvessel area (MVA), endothelial area (EA) and α-SMA CD31 Co-expression (α-SMA/CD31%) were compared with the DCE-MRI parameters. Results demonstrated that DCE-MRI with the new nanoparticle Gd@C-dots can noninvasively evaluate vascular permeability. K measured by DCE-MRI with Gd@C-dots is an accurate parameter for the characterization of tumor permeability. EA is a reliable microvessel parameter to evaluate vessel permeability.
恶性肿瘤血管通透性的评估在癌症的诊断和治疗中起着重要作用。使用 Gd 封装的碳点和 Gd-DTPA-BMA 作为对比剂的动态对比增强磁共振成像（DCE-MRI）在 4T1 小鼠乳腺癌和 HCC827 人非小细胞肺癌（NSCLC）异种移植模型中进行。肿瘤血管生成的组织病理学参数微血管密度（MVD）、微血管面积（MVA）、内皮面积（EA）和α-SMA-CD31 共表达（α-SMA/CD31%）与 DCE-MRI 参数进行了比较。结果表明，新型纳米粒子 Gd@C-dots 的 DCE-MRI 可以无创评估血管通透性。用 Gd@C-dots 进行 DCE-MRI 测量的 K 值是表征肿瘤通透性的准确参数。EA 是评估血管通透性的可靠微血管参数。
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