Williams Tracey A, Brunsdon Ruth K, Burton Karen L O, Drevensek Suzi, Brady Candice, Dale Russell C, Mohammad Shekeeb S
Kids Rehab, The Children's Hospital at Westmead, Sydney, Australia.
Kids Rehab, The Children's Hospital at Westmead, Sydney, Australia.
Brain Dev. 2019 Nov;41(10):894-900. doi: 10.1016/j.braindev.2019.07.007. Epub 2019 Jul 31.
Acute necrotizing encephalopathy (ANE) is a rare form of acute encephalopathy, predominantly occurring in childhood, which has a typical radiological phenotype including bilateral, symmetrical, diffusion-restricted lesions of the thalami; posterior putamen; cerebellum; and brainstem. To date, no study has systematically examined the long-term cognitive and psychological impact of ANE. The current study describes the neuropsychological outcomes of three paediatric cases of ANE, ranging from 18 months to 10 years post ANE. All three cases displayed inattention, fine motor difficulties and anxiety. Social difficulties were also reported in all cases. The severity of long-term impairment was associated with acute presentation, as well as convalescent neuroimaging. These findings highlight the need for detailed neuropsychological assessment and long-term rehabilitation.
急性坏死性脑病（ANE）是一种罕见的急性脑病形式，主要发生于儿童期，具有典型的放射学表型，包括丘脑、壳核后部、小脑和脑干的双侧对称性弥散受限性病变。迄今为止，尚无研究系统地探讨ANE的长期认知和心理影响。本研究描述了3例ANE儿科病例在ANE发病后18个月至10年的神经心理学转归。所有3例均表现出注意力不集中、精细运动困难和焦虑。所有病例均报告有社交困难。长期损害的严重程度与急性表现以及恢复期神经影像学检查有关。这些发现凸显了进行详细神经心理学评估和长期康复治疗的必要性。
