Borin M L, Azizova O A, Khodorov B I
Ukr Biokhim Zh (1978). 1988 May-Jun;60(3):56-60.
Tetracaine (1 mM), a local anesthetics, lowers a degree of aggregation of human thrombocytes which is induced by thrombin (0.15 u/ml) and suppresses its appearance. Aggregation of thrombocytes induced by phorbol ester, TPA (10-8 M), an activator of protein kinase C, is inhibited completely by the mentioned doses of the anesthetics. In the presence of tetracaine the release of intracellular Ca is lower to some extent, but then it surpasses the control level. It is established that under the action of ionophore A23187 tetracaine exerts no effect on mobilization of intracellular Ca2+.
丁卡因（1毫摩尔）是一种局部麻醉剂，可降低由凝血酶（0.15单位/毫升）诱导的人血小板聚集程度，并抑制其出现。佛波酯TPA（10-8摩尔）是蛋白激酶C的激活剂，由其诱导的血小板聚集被上述剂量的麻醉剂完全抑制。在丁卡因存在的情况下，细胞内钙的释放会在一定程度上降低，但随后会超过对照水平。已证实，在离子载体A23187的作用下，丁卡因对细胞内Ca2+的动员没有影响。
