Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
J Formos Med Assoc. 2019 Dec;118(12):1616-1622. doi: 10.1016/j.jfma.2019.07.022. Epub 2019 Aug 1.
BACKGROUND/PURPOSE: Oral cancer patients who survive for more than 5 years are supposed to have a reduced local cancer recurrence rate and survive longer. This study evaluated whether oral cancer patients who survived for more than 5 years might have reduced rates of local cancer recurrence, development of the second or third primary oral cancer, or the late regional cervical lymph node metastasis.
This study analyzed the clinical outcomes of 127 oral cancer patients (101 men and 26 women; mean age, 50.8 ± 12.1 years) who survived for more than 5 years after proper treatments of the initial primary oral cancers.
The 127 primary oral cancers included 117 squamous cell carcinomas (SCCs), 7 mucoepidermoid carcinomas, and 3 others. Of the 127 oral cancer patients who survived for more than 5 years, 47 survived for 5-9 years, 45 for 10-14 years, 22 for 15-19 years, 10 for 20-24 years, two for 25-29 years, and one for 30 years. Ten patients had local cancer recurrence 5.4 years-13.7 years, 12 patients had a second or a third primary oral cancer 3.6 years-17.2 years, and one mucoepidermoid carcinoma patient had a late regional cervical lymph node metastasis 11.9 years after total excision of the initial primary oral cancers.
Oral cancer patients who survive for more than 5 years may still have local cancer recurrence, the second or third primary oral cancer, or the late regional cervical lymph node metastasis but with a reduced rate.
背景/目的：存活时间超过 5 年的口腔癌患者局部癌症复发率较低，且存活时间更长。本研究评估了存活时间超过 5 年的口腔癌患者是否具有降低局部癌症复发率、发展第二或第三原发口腔癌或晚期区域性颈淋巴结转移的风险。
本研究分析了 127 例（101 名男性和 26 名女性；平均年龄 50.8±12.1 岁）经适当治疗后存活时间超过 5 年的初始原发性口腔癌患者的临床结果。
127 例原发性口腔癌包括 117 例鳞状细胞癌（SCC）、7 例黏液表皮样癌和 3 例其他类型。127 例存活时间超过 5 年的口腔癌患者中，47 例存活 5-9 年，45 例存活 10-14 年，22 例存活 15-19 年，10 例存活 20-24 年，2 例存活 25-29 年，1 例存活 30 年。10 例患者在 5.4 年-13.7 年内出现局部癌症复发，12 例患者在 3.6 年-17.2 年内出现第二或第三原发口腔癌，1 例黏液表皮样癌患者在完全切除初始原发性口腔癌 11.9 年后出现晚期区域性颈淋巴结转移。
存活时间超过 5 年的口腔癌患者仍可能出现局部癌症复发、第二或第三原发口腔癌或晚期区域性颈淋巴结转移，但复发率较低。
