Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Section of Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Nutr Metab Cardiovasc Dis. 2019 Oct;29(10):1077-1086. doi: 10.1016/j.numecd.2019.06.017. Epub 2019 Jun 24.
We investigated how vasoreactivity in the brachial artery and the forearm resistance vessels were related to fat distribution and tissue volume, using both traditional imaging analysis and a new technique, called "Imiomics", whereby vasoreactivity was related to each of the >2M 3D image elements included in the whole-body magnetic resonance imaging (MRI).
In 326 subjects in the Prospective investigation of Obesity, Energy and Metabolism (POEM) study (all aged 50 years), endothelium-dependent vasodilation was measured by acetylcholine infusion in the brachial artery (EDV) and flow-mediated vasodilation (FMD). Fat distribution was evaluated by dual-energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI). EDV, but not FMD, was significantly related to total fat mass, liver fat, subcutaneous (SAT) and visceral (VAT) adipose tissue in a negative fashion in women, but not in men. Using Imiomics, an inverse relationship was seen between EDV and a local tissue volume of SAT in both the upper part of the body, as well as the gluteo-femoral part and the medial parts of the legs in women. Also the size of the liver, heart and VAT was inversely related to EDV. In men, less pronounced relationships were seen. FMD was also significantly related to local tissue volume of upper-body SAT and liver fat in women, but less so in men.
EDV, and to a lesser degree also FMD, were related to liver fat, SAT and VAT in women, but less so in men. Imiomics both confirmed findings from traditional methods and resulted in new, more detailed results.
我们通过传统的影像学分析和一种新的技术——“成像组学”，研究了肱动脉和前臂阻力血管的血管反应性与脂肪分布和组织体积之间的关系，其中“成像组学”将血管反应性与全身磁共振成像（MRI）中包含的超过 200 万个 3D 图像元素中的每一个都相关联。
在 Prospective investigation of Obesity，Energy and Metabolism（POEM）研究的 326 名受试者（年龄均为 50 岁）中，通过乙酰胆碱输注测量肱动脉的内皮依赖性血管舒张（EDV）和血流介导的血管舒张（FMD）。通过双能 X 射线吸收法（DXA）和磁共振成像（MRI）评估脂肪分布。在女性中，EDV 与总脂肪量、肝脂肪、皮下（SAT）和内脏（VAT）脂肪组织呈负相关，但在男性中则不然。使用成像组学，在女性中，EDV 与上半身 SAT 的局部组织体积呈负相关，在臀部-股部以及腿部的内侧部分也是如此。同时，肝脏、心脏和 VAT 的大小与 EDV 呈负相关。在男性中，相关性不那么明显。FMD 也与女性上半身 SAT 的局部组织体积和肝脂肪显著相关，但在男性中则不然。
EDV，在一定程度上也包括 FMD，与女性的肝脂肪、SAT 和 VAT 相关，但在男性中则不然。成像组学既证实了传统方法的发现，又产生了新的、更详细的结果。
