Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Cognitive Neuroscience, Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran; Division of cognitive Neuroscience, Department of Psychology, Faculty of Education and Psychology, University of Tabriz, Tabriz, Iran.
Genomics. 2020 Mar;112(2):1330-1334. doi: 10.1016/j.ygeno.2019.07.024. Epub 2019 Aug 1.
Several single nucleotide polymorphisms (SNPs) of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the endocannabinoids, have been shown to be associated with many neuropsychiatric disorders. Here, FAAH rs2295633 was studied in ADHD and case-control healthy children. There was a significant difference in the allele frequency (P = .04) and genotype distribution (P = .04) of the FAAH rs2295633 between ADHD cases and controls. The ADHD children appeared to have less of TT genotype (OR 0.396, 95% CI 0.178-0.884, p = .024) and T allele (OR 0.658, 95% CI 0.440-0.982, p = .04). To our best knowledge, this is the first statistical significant association between FAAH rs2295633 genotype and ADHD disorder. Larger sample sizes and functional studies are warranted to explore the clinical utility of FAAH genotyping as a possible marker for increased ADHD risk in children.
几种脂肪酸酰胺水解酶（FAAH）的单核苷酸多态性（SNPs），即内源性大麻素的降解酶，已被证明与许多神经精神疾病有关。在这里，研究了 ADHD 和病例对照健康儿童中的 FAAH rs2295633。ADHD 病例和对照组之间 FAAH rs2295633 的等位基因频率（P=0.04）和基因型分布（P=0.04）存在显著差异。ADHD 儿童似乎 TT 基因型（OR 0.396，95%CI 0.178-0.884，p=0.024）和 T 等位基因（OR 0.658，95%CI 0.440-0.982，p=0.04）较少。据我们所知，这是 FAAH rs2295633 基因型与 ADHD 障碍之间首次具有统计学意义的关联。需要更大的样本量和功能研究来探索 FAAH 基因分型作为儿童 ADHD 风险增加的可能标志物的临床效用。
