Sótonyi P, Kékesi V, Somogyi E
Dept. of Forensic Medicine, Semmelweis University of Medicine, Budapest, Hungary.
Acta Morphol Hung. 1987;35(3-4):91-104.
The paper presents new evidence of the vasoactivity of cardiac glycosides in the myocardium. Experiments were performed on the in situ dog heart. The present study primarily focuses on the analysis of K-strophantoside induced topo-optical and thermographic alterations in acute myocardial ischemia. The strong binding of K-strophantoside to the coronary vessel wall and the endothelial cells was found to be accompanied by vasoconstriction in the regionally ischemic heart muscle. The potential clinical impact of these findings on therapy is briefly evaluated.
该论文展示了强心苷在心肌中血管活性的新证据。实验是在原位犬心脏上进行的。本研究主要聚焦于分析毒毛旋花子苷 K 在急性心肌缺血中引起的拓扑光学和热成像改变。发现毒毛旋花子苷 K 与冠状动脉血管壁和内皮细胞的强烈结合伴随着局部缺血心肌区域的血管收缩。简要评估了这些发现对治疗的潜在临床影响。
