Fiaccadori E, Del Canale S, Coffrini E, Vitali P, Antonucci C, Cacciani G, Mazzola I, Guariglia A
Istituto di Clinica Medica e Nefrologia, Università di Parma, Italy.
Am J Clin Nutr. 1988 Sep;48(3):680-5. doi: 10.1093/ajcn/48.3.680.
In 90 patients with hypercapnic-hypoxemic chronic obstructive pulmonary disease (COPD), noninvasive anthropometric and biochemical nutritional indices were measured to assess the prevalence and features of malnutrition in COPD and to analyze the relationship between nutritional depletion and the severity of the disease. A significant inverse relationship was found between PaCO2 and body weight; a parallel decrease of both somatic proteins and body-energy stores of fat appears to be paired with decreasing body weight. Deterioration of nutritional status occurred in the COPD patients considered despite seemingly adequate calorie and protein intakes, although in patients with more severe impairment of pulmonary gas exchange, calorie intake was significantly lower compared with basal energy expenditure. In the course of hypercapnic-hypoxemic COPD malnutrition is common, it is related to the severity of the disease as judged by the need for hospitalization and degree of impairment of gas exchange, and it may be present despite apparently adequate nutrient intake.
对90例高碳酸血症 - 低氧血症型慢性阻塞性肺疾病（COPD）患者进行无创人体测量和生化营养指标测定，以评估COPD患者营养不良的患病率和特征，并分析营养消耗与疾病严重程度之间的关系。发现动脉血二氧化碳分压（PaCO2）与体重之间存在显著的负相关关系；随着体重下降，体细胞蛋白和身体脂肪能量储备似乎同时减少。尽管热量和蛋白质摄入量看似充足，但COPD患者的营养状况仍出现恶化，不过在肺气体交换受损更严重的患者中，热量摄入量与基础能量消耗相比显著降低。在高碳酸血症 - 低氧血症型COPD病程中，营养不良很常见，根据住院需求和气体交换受损程度判断，它与疾病严重程度相关，并且即使营养摄入量看似充足也可能存在。
