Chabane M H, Leynadier F, Halpern G M, Dry J
Centre D'Allergie, Hopital Rothschild, Paris, France.
Ann Allergy. 1988 Sep;61(3):216-9.
Serum sickness can be induced by several heterologous proteins. Two patients undergoing rush immunotherapy developed clinical symptoms of serum sickness. One patient received a mite and grass pollens mixture and the second patient a wasp and yellow-jacket venoms mixture. Precipitating antibodies against some allergens used for immunotherapy were found in their serum during the disease but not in the sera drawn before immunotherapy and two and three months after. Pathologic findings showed a leukocytoclastic vasculitis. Pathogenesis of this complication is discussed.
血清病可由多种异种蛋白诱发。两名接受快速免疫疗法的患者出现了血清病的临床症状。一名患者接受了螨虫和草花粉混合物，另一名患者接受了黄蜂和黄胡蜂毒液混合物。在疾病期间，他们的血清中发现了针对一些用于免疫疗法的过敏原的沉淀抗体，但在免疫疗法前以及免疫疗法后两个月和三个月抽取的血清中未发现。病理检查结果显示为白细胞破碎性血管炎。本文讨论了这种并发症的发病机制。
