Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93-6 Ji-dong, Paldal-gu, Suwon, Kyonggi-do, 442-723, Republic of Korea.
Department of Family Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 271, Cheon Bo-ro, Uijeong bu-si, Gyeonggi-do, 480-717, Republic of Korea.
Brain Stimul. 2019 Nov-Dec;12(6):1556-1564. doi: 10.1016/j.brs.2019.07.020. Epub 2019 Jul 25.
Although some studies have reported significant reductions in food cravings following the single-session of repetitive transcranial magnetic stimulation (rTMS), there is little research on the effects of multi-session of rTMS on food consumption and body weight in obese subjects.
We conducted 4-week randomized, sham-controlled, single-blind, parallel-group trial to examine the effect of rTMS on body weight in obese adults.
Forty-three obese patients (body mass index [BMI] ≥25 kg/m) aged between 18 and 70 years were randomized to the sham or real treatment group (21 in the TMS group and 22 in the sham treatment group). A total of 8 sessions of rTMS targeting the left dorsolateral prefrontal cortex (DLPFC) was provided over a period of 4 weeks. The primary outcome measure was weight change in kilograms from baseline to 4 weeks. Secondary endpoints included changes in anthropometric measures, cardiovascular risk factors, food intake, and appetite.
Participants in the rTMS group showed significantly greater weight loss from baseline following the 8 session of rTMS (-2.75 ± 2.37 kg vs. 0.38 ± 1.0 kg, p < 0.01). Consistent with weight loss, there was a significant reduction in fat mass and visceral adipose tissue at week 4 in the rTMS group compared with the control group (p < 0.01). After the 8 sessions of rTMS, the TMS group consumed fewer total kilocalories and carbohydrates per day than the control group (p < 0.05).
8 sessions of HF rTMS delivered to the left DLPFC were effective in inducing weight loss and decreasing food intake in obese patients.
Clinical trial registered with the Clinical Trials Registry at http://cris.cdc.go.kr (KCT0002548).
尽管一些研究报告称，单次重复经颅磁刺激（rTMS）可显著减少食物渴望，但关于 rTMS 对肥胖受试者的食物消耗和体重的多疗程影响的研究甚少。
我们进行了为期 4 周的随机、假对照、单盲、平行组试验，以检验 rTMS 对肥胖成年人体重的影响。
43 名肥胖患者（体重指数 [BMI]≥25kg/m）年龄在 18 至 70 岁之间，随机分为假治疗组或真治疗组（rTMS 组 21 例，假治疗组 22 例）。在 4 周的时间内共进行 8 次针对左侧背外侧前额叶皮层（DLPFC）的 rTMS。主要观察指标是从基线到 4 周时的体重变化（kg）。次要终点包括人体测量指标、心血管危险因素、食物摄入和食欲的变化。
rTMS 组在 8 次 rTMS 治疗后，体重较基线明显下降（-2.75±2.37kg 比 0.38±1.0kg，p<0.01）。与体重减轻一致，rTMS 组在第 4 周时脂肪质量和内脏脂肪组织明显低于对照组（p<0.01）。在 8 次 rTMS 治疗后，rTMS 组每天摄入的总热量和碳水化合物比对照组少（p<0.05）。
8 次高频 rTMS 治疗左侧 DLPFC 可有效诱导肥胖患者体重减轻和减少食物摄入。
在中国临床试验注册中心注册，网址为 http://cris.cdc.go.kr（注册号 KCT0002548）。
