Department of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Sydney Centres for Thrombosis and Haemostasis, NSW Health Pathology, Westmead Hospital, Westmead, New South Wales, Australia.
Am J Hematol. 2019 Nov;94(11):1290-1296. doi: 10.1002/ajh.25606. Epub 2019 Aug 29.
Lupus anticoagulants (LAs) are a laboratory representation of the clinical syndrome of antiphospholipid syndrome (APS), and can also arise in other pathological states. Laboratory testing for LA is complex and three separate recent guidelines have been published. One test, the Russell viper venom time (RVVT), is the mandated laboratory test for inclusion in LA identification/exclusion in all three guidance documents. This is because the the RVVT is recognized to have great sensitivity for LA, with this generally recognized to be greater than that of most other LA screening assays. However, the RVVT is also very sensitive to the presence of many anticoagulant drugs, which diminishes its specificity for LA. Various strategies can be used to improve LA specificity and reduce anticoagulant assay interference.
狼疮抗凝物（LA）是抗磷脂综合征（APS）临床综合征的实验室表现，也可能出现在其他病理状态中。LA 的实验室检测很复杂，最近已经发布了三个不同的指南。其中一个测试，即 Russell 蝰蛇毒时间（RVVT），是所有三个指南中 LA 鉴定/排除的强制性实验室检测。这是因为 RVVT 被认为对 LA 具有很高的敏感性，通常认为其敏感性大于大多数其他 LA 筛选检测。然而，RVVT 也非常敏感于许多抗凝药物的存在，这降低了其对 LA 的特异性。可以使用各种策略来提高 LA 的特异性并减少抗凝剂检测干扰。
