Enginar A U, Kacar C
Bratisl Lek Listy. 2019;120(8):586-592. doi: 10.4149/BLL_2019_096.
In recent years, neutrophil-lymphocyte rate (NLR) and platelet-lymphocyte rate (PLR) are reported to be increasing in plenty of rheumatological diseases and the latter rates to be disease activity indicators. In our study, we aimed to search for the difference in NLR and PLR before and after the treatment, their relationship with the disease activity and their seasonal differences in patients using anti-TNF medication for rheumatoid arthritis (RA) and ankylosing spondylitis (AS) while.
Sixty-eight RA and 203 AS patients using anti-TNF medication for at least 6 months were included in the study. Patients with acute infection, diabetes, hypertension, cancer, renal failure and liver failure were excluded from the study. NLR, PLR, seasonal differences and the disease activities of the patients were evaluated retrospectively.
We determined that NLR and PLR are strongly correlated with disease activity, erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP). In addition, we determined that disease activity, thrombocytes and PLR are increased in spring and winter, especially in patients with RA.
NLR and PLR are simple, cheap, and easily accessible parameters which can be used to evaluate disease activity and treatment response before and after anti-TNF treatment. Further studies are needed to enlighten the effect of seasonal differences on disease activity (Tab. 2, Fig. 2, Ref. 43).
近年来，据报道在许多风湿性疾病中中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞比率（PLR）呈上升趋势，且后者比率为疾病活动指标。在我们的研究中，我们旨在探寻类风湿关节炎（RA）和强直性脊柱炎（AS）患者使用抗TNF药物治疗前后NLR和PLR的差异、它们与疾病活动的关系以及它们的季节差异。
本研究纳入了68例使用抗TNF药物至少6个月的RA患者和203例AS患者。急性感染、糖尿病、高血压、癌症、肾衰竭和肝衰竭患者被排除在研究之外。对患者的NLR、PLR、季节差异和疾病活动进行回顾性评估。
我们确定NLR和PLR与疾病活动、红细胞沉降率（ESR）和C反应蛋白（CRP）密切相关。此外，我们确定疾病活动、血小板和PLR在春季和冬季增加，尤其是RA患者。
NLR和PLR是简单、廉价且易于获取的参数，可用于评估抗TNF治疗前后的疾病活动和治疗反应。需要进一步研究以阐明季节差异对疾病活动的影响（表2，图2，参考文献43）。
