中性粒细胞与血小板和淋巴细胞的比例与类风湿性关节炎的疾病活动相关。
Neutrophil- and platelet-to-lymphocyte ratios are correlated with disease activity in rheumatoid arthritis.
作者信息
Fu Haitao, Qin Baodong, Hu Zhide, Ma Ning, Yang Min, Wei Tingting, Tang Qingqing, Huang Yuanlan, Huang Fenglou, Liang Yan, Yang Zaixing, Zhong Renqian
出版信息
Clin Lab. 2015;61(3-4):269-73. doi: 10.7754/clin.lab.2014.140927.
BACKGROUND
Both neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are reported to be increased in various inflammation-related diseases, but their clinical significance in rheumatoid arthritis (RA) remains unclear. The aim of the present study was to explore whether NLR and PLR were candidate indices for RA disease-activity assessment.
METHODS
The medical records of 128 RA patients and 78 healthy individuals were retrospectively reviewed. Correlations of NLR and PLR with the disease activity of RA were evaluated.
RESULTS
NLR and PLR were increased significantly in RA patients. NLR was significantly positively correlated with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and Disease-Activity Score including 28 joints (DAS28) in RA patients, while PLR was positively correlated with CRP and DAS28, but not with ESR.
CONCLUSIONS
Both NLR and PLR values may prove to be potential indices for RA disease-activity assessment.
背景
据报道，在各种炎症相关疾病中，中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）均升高，但其在类风湿关节炎（RA）中的临床意义仍不明确。本研究的目的是探讨NLR和PLR是否为RA疾病活动度评估的候选指标。
方法
回顾性分析128例RA患者和78例健康个体的病历。评估NLR和PLR与RA疾病活动度的相关性。
结果
RA患者的NLR和PLR显著升高。RA患者中，NLR与C反应蛋白（CRP）、红细胞沉降率（ESR）以及包括28个关节的疾病活动评分（DAS28）显著正相关，而PLR与CRP和DAS28正相关，但与ESR无关。
结论
NLR和PLR值可能是RA疾病活动度评估的潜在指标。
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