1 Cardiological Outpatients, Medicor, Myszków, Poland.
2 Department of Pediatrics, SMDZ in Zabrze, SUM in Katowice, Poland.
J Renin Angiotensin Aldosterone Syst. 2019 Jul-Sep;20(3):1470320319862662. doi: 10.1177/1470320319862662.
The most common disease associated with the presence of kidney cysts in the population is autosomal dominant polycystic kidney disease (ADPKD), which finally leads to end-stage renal disease.
The study evaluated serum and urinary concentration of angiotensinogen (AGT) and interleukin 18 (IL-18) in a group of 39 children with renal cysts of different aetiology.
Serum and urinary AGT concentration in children with renal cysts was higher compared to controls, regardless of the underlying background and gender. Serum IL-18 concentration was lower, in contrast, and the concentration of IL-18 in the urine did not differ between affected and healthy children. Negative correlation between urinary IL-18 concentration and systolic and mean arterial blood pressure was noted.
Higher AGT levels in serum and urine in children with renal cysts may indicate the activation of the renin-angiotensin-aldosterone system, including its intrarenal part, even before the onset of hypertension. Lower serum concentration of IL-18 in children with kidney cysts may indicate the loss of the protective role of this cytokine with the occurrence of hypertension.
与人群中肾囊肿相关的最常见疾病是常染色体显性多囊肾病（ADPKD），最终导致终末期肾病。
本研究评估了一组 39 名不同病因肾囊肿患儿的血清和尿液中血管紧张素原（AGT）和白细胞介素 18（IL-18）的浓度。
与对照组相比，无论潜在背景和性别如何，患有肾囊肿的儿童的血清和尿液 AGT 浓度均较高。相反，血清 IL-18 浓度较低，而受影响和健康儿童尿液中的 IL-18 浓度无差异。尿中 IL-18 浓度与收缩压和平均动脉压呈负相关。
肾囊肿患儿血清和尿液中 AGT 水平升高可能表明肾素-血管紧张素-醛固酮系统（包括其肾内部分）的激活，甚至在高血压发生之前。肾囊肿患儿血清中 IL-18 浓度降低可能表明这种细胞因子的保护作用丧失，同时发生高血压。
