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分枝杆菌甘露糖封盖的脂阿拉伯甘露聚糖：连接固有免疫和适应性免疫的调节剂。

Mycobacterial mannose-capped lipoarabinomannan: a modulator bridging innate and adaptive immunity.

机构信息

a State Key Laboratory of Virology and Medical Research Institue, Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, Wuhan University School of Medicine , Wuhan , People's Republic of China.

b The eighth hospital of Wuhan , Wuhan , People's Republic of China.

出版信息

Emerg Microbes Infect. 2019;8(1):1168-1177. doi: 10.1080/22221751.2019.1649097.

DOI:10.1080/22221751.2019.1649097
PMID:31379262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6713153/
Abstract

Mannose-capped lipoarabinomannan (ManLAM) is a high molecular mass amphipathic lipoglycan identified in pathogenic () and Bacillus Calmette-Guérin (BCG). ManLAM, serves as both an immunogen and a modulator of the host immune system, and its critical role in mycobacterial survival during infection has been well-characterized. ManLAM can be recognized by various types of receptors on both innate and adaptive immune cells, including macrophages, dendritic cells (DCs), neutrophils, natural killer T (NKT) cells, T cells and B cells. MamLAM has been shown to affect phagocytosis, cytokine production, antigen presentation, T cell activation and polarization, as well as antibody production. Exploring the mechanisms underlying the roles of ManLAM during mycobacterial infection will aid in improving tuberculosis (TB) prevention, diagnosis and treatment interventions. In this review, we highlight the interaction between ManLAM and receptors, intracellular signalling pathways triggered by ManLAM and its roles in both innate and adaptive immune responses.

摘要

甘露糖 capped 脂阿拉伯甘露聚糖 (ManLAM) 是一种高分子量的两亲脂聚糖，在致病性 （）和卡介苗 (BCG) 中被鉴定出来。ManLAM 既是免疫原又是宿主免疫系统的调节剂，其在感染期间对分枝杆菌存活的关键作用已得到充分证实。ManLAM 可被先天和适应性免疫细胞上的各种类型的受体识别，包括巨噬细胞、树突状细胞 (DC)、中性粒细胞、自然杀伤 T (NKT) 细胞、T 细胞和 B 细胞。MamLAM 已被证明影响吞噬作用、细胞因子产生、抗原呈递、T 细胞激活和极化以及抗体产生。探索 ManLAM 在分枝杆菌感染过程中的作用机制将有助于改善结核病 (TB) 的预防、诊断和治疗干预。在这篇综述中，我们强调了 ManLAM 与受体之间的相互作用、ManLAM 触发的细胞内信号通路及其在先天和适应性免疫反应中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/6713153/9a5c1ad51c4b/TEMI_A_1649097_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/6713153/097cb2c9b0fc/TEMI_A_1649097_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/6713153/1e151a716fb7/TEMI_A_1649097_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/6713153/9a5c1ad51c4b/TEMI_A_1649097_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/6713153/097cb2c9b0fc/TEMI_A_1649097_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/6713153/1e151a716fb7/TEMI_A_1649097_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/6713153/9a5c1ad51c4b/TEMI_A_1649097_F0003_OC.jpg

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本文引用的文献

1
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J Leukoc Biol. 2019 Aug;106(2):275-282. doi: 10.1002/JLB.MR0318-095RR. Epub 2019 Apr 2.
2
Tuberculosis.肺结核。
Lancet. 2019 Apr 20;393(10181):1642-1656. doi: 10.1016/S0140-6736(19)30308-3. Epub 2019 Mar 20.
3
Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan Induces IL-10-Producing B Cells and Hinders CD4Th1 Immunity.结核分枝杆菌甘露糖封端的脂阿拉伯甘露聚糖诱导产生白细胞介素-10的B细胞并阻碍CD4 Th1免疫。
卡介苗治疗膀胱癌及其与肿瘤微环境的相互作用。
Clin Microbiol Rev. 2025 Jun 12;38(2):e0021224. doi: 10.1128/cmr.00212-24. Epub 2025 Mar 20.
4
ZnI-Mediated -Glycosylations of Various Constrained Glycosyl Donors: Recent Advances in -Selective Glycosylations.碘化锌介导的各种受限糖基供体的α-糖基化反应：α-选择性糖基化反应的最新进展
Molecules. 2024 Oct 4;29(19):4710. doi: 10.3390/molecules29194710.
5
and host interactions in the manifestation of tuberculosis.以及宿主在结核病表现中的相互作用。
J Clin Tuberc Other Mycobact Dis. 2024 Jun 14;36:100458. doi: 10.1016/j.jctube.2024.100458. eCollection 2024 Aug.
6
Macrophages exploit the mannose receptor and JAK-STAT1-MHC-II pathway to drive antigen presentation and the antimycobacterial immune response after BCG vaccination.巨噬细胞利用甘露糖受体和 JAK-STAT1-MHC-II 途径来驱动抗原呈递和卡介苗接种后的抗分枝杆菌免疫反应。
Acta Biochim Biophys Sin (Shanghai). 2024 Jun 18;56(8):1130-1144. doi: 10.3724/abbs.2024100.
7
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8
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iScience. 2019 Jan 25;11:13-30. doi: 10.1016/j.isci.2018.11.039. Epub 2018 Dec 4.
4
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9
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