Onifer Stephen M, Sozio Randall S, Long Cynthia R
Palmer Center for Chiropractic Research, Palmer College of Chiropractic, 741 Brady Street, Davenport, IA 52803-5214, USA.
Evid Based Complement Alternat Med. 2019 Jul 15;2019:2878352. doi: 10.1155/2019/2878352. eCollection 2019.
Chronic pain is quite prevalent and causes significant disabilities and socioeconomic burdens. Spinal manipulative therapy and other manipulative therapies are used to manage chronic pain. There is a critical knowledge gap about mechanisms and sites of action in spinal manipulative therapy pain relief, especially the short-term analgesia that occurs following a treatment. Endocannabinoids are an activity-dependent neurotransmitter system that acts as a short-term synaptic circuit breaker. This review describes both clinical research and basic research evidence suggesting that endocannabinoids contribute to short-term manipulative therapy analgesia. Determining endocannabinoids involvement in spinal manipulative therapy will improve its clinical efficacy when results from basic science and clinical research are translated.
慢性疼痛相当普遍，会导致严重的残疾和社会经济负担。脊柱推拿疗法和其他手法治疗被用于管理慢性疼痛。在脊柱推拿疗法缓解疼痛的机制和作用部位方面存在关键的知识空白，尤其是治疗后出现的短期镇痛。内源性大麻素是一种依赖活动的神经递质系统，可作为短期突触断路器。这篇综述描述了临床研究和基础研究证据，表明内源性大麻素有助于短期手法治疗镇痛。当基础科学和临床研究的结果转化应用时，确定内源性大麻素在脊柱推拿疗法中的作用将提高其临床疗效。
