TIMP-2: An Endogenous Angiogenesis Inhibitor with Distinct Antitumoral Properties.
作者信息
Bourboulia Dimitra, Jensen-Taubman Sandra, Stetler-Stevenson William G
机构信息
Radiation Oncology Branch, Center for Cancer Research, NCI/NIH, Advanced Technology Center, Bethesda, Maryland.
Chief, Extracellular Matrix Pathology Section, Radiation Oncology Branch, Center for Cancer Research, NCI/NIH, Advanced Technology Center, Bethesda, Maryland.
出版信息
Treat Strategies Hematol. 2012;2(1):31-35.
Abstract
摘要
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本文引用的文献
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Tumor angiogenesis: molecular pathways and therapeutic targets.肿瘤血管生成：分子途径和治疗靶点。
Nat Med. 2011 Nov 7;17(11):1359-70. doi: 10.1038/nm.2537.
2
Endogenous angiogenesis inhibitor blocks tumor growth via direct and indirect effects on tumor microenvironment.内源性血管生成抑制剂通过对肿瘤微环境的直接和间接作用来抑制肿瘤生长。
Am J Pathol. 2011 Nov;179(5):2589-600. doi: 10.1016/j.ajpath.2011.07.035. Epub 2011 Sep 18.
3
An integrin-binding N-terminal peptide region of TIMP-2 retains potent angio-inhibitory and anti-tumorigenic activity in vivo.TIMP-2 的整合素结合 N 端肽区域在体内保留了强效的血管生成抑制和抗肿瘤活性。
Peptides. 2011 Sep;32(9):1840-8. doi: 10.1016/j.peptides.2011.08.010. Epub 2011 Aug 16.
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Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner.平衡血管生成调节因子以特定阶段的方式控制癌症进展和存活的速度。
Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9939-44. doi: 10.1073/pnas.1105041108. Epub 2011 May 27.
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The anti-angiogenic peptide, loop 6, binds insulin-like growth factor-1 receptor.抗血管生成肽，环 6，与胰岛素样生长因子-1 受体结合。
J Biol Chem. 2010 Dec 31;285(53):41886-95. doi: 10.1074/jbc.M110.166439. Epub 2010 Oct 12.
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Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion.基质金属蛋白酶（MMPs）和金属蛋白酶组织抑制剂（TIMPs）：肿瘤细胞黏附中的正向和负向调节因子。
Semin Cancer Biol. 2010 Jun;20(3):161-8. doi: 10.1016/j.semcancer.2010.05.002. Epub 2010 May 12.
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Sci Signal. 2008 Jul 8;1(27):re6. doi: 10.1126/scisignal.127re6.
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