Arneth Borros M
Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University Hospital of the Universities of Giessen and Marburg UKGM, Justus Liebig University Giessen, Giessen, Germany.
Autoimmune Dis. 2019 Jul 9;2019:2135423. doi: 10.1155/2019/2135423. eCollection 2019.
Multiple well-recognized conditions, such as Lambert-Eaton myasthenic syndrome (LEMS) and myasthenia gravis (MG), have been associated with neuronal antibodies.
A search was performed using Embase, PubMed, and CINAHL. An initial search of each database was conducted using keywords and terms related to the aim of the current review. Additional articles were obtained by examining the reference lists and citations in the selected records.
The studies identified through the search process used different designs and methods to explore neuronal antibodies and associated syndromes. Previous studies have shown that neurological and psychiatric disorders can be mediated and influenced by various antibodies. The identification of autoantibodies can help with the accurate diagnosis of conditions and commencement of early treatment.
A review of selected studies identified in the literature implicated that classic anti-neuronal antibodies, such as anti-Ri and anti-Hu, play a role in the development of neurological diseases. More recent studies have indicated that other novel antibodies act on neuronal cell surface antigens to contribute to the development of neurological disorders.
Existing research provides evidence revealing a spectrum of antibodies linked to the development and progression of neurological diseases. However, further antibody testing and studies should be performed to validate the relationship between conditions and antibodies.
多种广为人知的病症，如兰伯特-伊顿肌无力综合征（LEMS）和重症肌无力（MG），都与神经元抗体有关。
使用Embase、PubMed和CINAHL进行检索。最初对每个数据库进行检索时，使用了与本次综述目的相关的关键词和术语。通过查阅所选记录中的参考文献列表和引用文献获取了更多文章。
通过检索过程确定的研究采用了不同的设计和方法来探索神经元抗体及相关综合征。先前的研究表明，神经和精神疾病可由多种抗体介导和影响。自身抗体的鉴定有助于准确诊断病情并尽早开始治疗。
对文献中所选研究的综述表明，经典的抗神经元抗体，如抗Ri和抗Hu，在神经疾病的发展中起作用。最近的研究表明，其他新型抗体作用于神经元细胞表面抗原，促进了神经疾病的发展。
现有研究提供的证据揭示了一系列与神经疾病的发生和发展相关的抗体。然而，应进行进一步的抗体检测和研究，以验证病情与抗体之间的关系。
