Liu Song, Wang Meng, Lu Xiaofeng, Feng Min, Wang Feng, Zheng Liming, Guan Wenxian
Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Department of General Surgery, Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, China.
Front Oncol. 2019 Jul 15;9:637. doi: 10.3389/fonc.2019.00637. eCollection 2019.
Surgical site infection (SSI) hampers the advantages of surgical management, which requires early forecast particularly in patients receiving colorectal surgery. This study is to explore potential relationship between individual abdominal anatomic characteristics including subcutaneous fat thickness (SFT), rectus abdominis thickness (RAT), and abdomen depth (AD), with the incidence of SSI in elective radical resection of colon malignancy. This retrospective case-control study has recruited 55 patients in each SSI and non-SSI group with propensity score match method. Demographics, clinical attributes, and pre- and intra-operative information were compared between groups with univariate analysis to elicit significant parameters, which were subsequently brought into logistic regression and receiver-operating characteristic (ROC) analysis. Patients with SSI showed lower preoperative albumin ( = 0.0022), higher RAT ( = 0.014), AD ( = 0.029), and the multiplied value (RAT × AD) ( = 0.0026) contrasted with patients without SSI. Logistic regression demonstrated RAT × AD as an independent risk factor for SSI (OR = 1.007, < 0.001) and a biomarker for SSI prediction (AUC = 0.83, 95% CI: 0.74 ~ 0.91). Preoperative RAT and abdomen depth are associated with the risk of postoperative SSI in patients receiving elective radical resection of colon cancer. www.researchregistry.com, identifier researchregistry3669.
手术部位感染（SSI）削弱了手术治疗的优势，这需要早期预测，尤其是在接受结直肠手术的患者中。本研究旨在探讨个体腹部解剖特征，包括皮下脂肪厚度（SFT）、腹直肌厚度（RAT）和腹部深度（AD）与择期结肠癌根治性切除术中SSI发生率之间的潜在关系。本回顾性病例对照研究采用倾向评分匹配法，在SSI组和非SSI组各招募了55例患者。通过单因素分析比较两组之间的人口统计学、临床特征以及术前和术中信息，以找出显著参数，随后将这些参数纳入逻辑回归和受试者工作特征（ROC）分析。与无SSI的患者相比，SSI患者术前白蛋白水平较低（ = 0.0022），RAT较高（ = 0.014），AD较高（ = 0.029），且乘积值（RAT×AD）较高（ = 0.0026）。逻辑回归显示RAT×AD是SSI的独立危险因素（OR = 1.007， < 0.001），也是SSI预测的生物标志物（AUC = 0.83，95%CI：0.74 ~ 0.91）。术前RAT和腹部深度与接受择期结肠癌根治性切除术患者术后SSI的风险相关。www.researchregistry.com，标识符researchregistry3669。
