Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, Department of Hematology and Cellular Therapy, Créteil, France; University Paris-Est Créteil (UPEC), Créteil, France.
Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, Department of Hematology and Cellular Therapy, Créteil, France; University Paris-Est Créteil (UPEC), Créteil, France.
Biol Blood Marrow Transplant. 2019 Dec;25(12):2510-2513. doi: 10.1016/j.bbmt.2019.07.035. Epub 2019 Aug 2.
Among 419 consecutive allogeneic hematopoietic cell transplant recipients, we observed 17 (4.0%) cases of toxoplasmosis at a median time of day 45 (range, 6 to 322) after transplant. Seven of these 17 cases occurred before day 30 after transplant. Because of the lack of PCR screening and trimethoprim-sulfamethoxazole prophylaxis before engraftment, the diagnosis of toxoplasmosis was late, and 5 of these 7 patients died. Analyzing these cases, early Toxoplasma blood PCR screening, starting from transplant, is crucial.
在 419 例连续的异基因造血细胞移植受者中，我们在移植后中位数时间为 45 天（范围为 6 至 322 天）时观察到 17 例（4.0%）弓形虫病。其中 7 例发生在移植后 30 天之前。由于在植入前缺乏 PCR 筛查和甲氧苄啶-磺胺甲噁唑预防，弓形虫病的诊断较晚，其中 5 例患者死亡。对这些病例进行分析后，我们认为从移植开始进行早期的弓形虫血 PCR 筛查至关重要。
