Pathmarajah T, Chu S, Sieunarine K
Department of Vascular and Endovascular Surgery, Royal Perth Hospital, Perth, Australia.
Department of Plastic and Reconstructive Surgery, Fiona Stanley Hospital, Perth, Australia.
Int J Surg Case Rep. 2019;61:238-241. doi: 10.1016/j.ijscr.2019.07.063. Epub 2019 Jul 25.
Mycotic aneurysms are an uncommon occurrence, withStaphylococcus and Salmonella species found to be the causative pathogen in up to 95% of cases. We believe this is the first described case of a common femoral artery mycotic aneurysm due to Listeria monocytogenes.
A 66-year-old male presented with a two-month history of an increasing painful mass in his left groin, on the background of immunosuppression treatment for ankylosing spondylitis. He was afebrile on assessment, with a normal white cell count. Contrast enhanced CT scan showed a common femoral artery aneurysm, with no infective features. His aneurysm was excised and repaired with a Dacron tube graft. L. monocytogenes was cultured from the aneurysm tissue, and he was commenced on appropriate antibiotic treatment. The prosthetic graft was also replaced with a venous bypass of the aneurysm.
L. monocytogenes is a rare cause of mycotic aneurysm with less than 40 cases reported in the literature. Immunosuppression is a recognised risk factor for Listerial infections. Immunocompromised patients may not display typical clinical or biochemical features associated with a mycotic aneurysm. Prosthetic graft infections are associated with significant mortality, with excision of the prosthetic material and venous reconstruction associated with good outcomes for eradicating infection.
This report highlights the importance of obtaining intraoperative tissue samples for microbiological and histopathological assessment in immunocompromised patients. This is important for the detection of rare organisms such as L.monocytogenes, requiring targeted antibiotic therapy. Inappropriate treatment of Listerial infections can result in serious invasive illness.
真菌性动脉瘤并不常见,在高达95%的病例中,发现葡萄球菌和沙门氏菌是致病病原体。我们认为这是首例因单核细胞增生李斯特菌导致的股总动脉真菌性动脉瘤病例。
一名66岁男性,在接受强直性脊柱炎免疫抑制治疗的背景下,出现左侧腹股沟区肿物且疼痛逐渐加重两个月。评估时体温正常,白细胞计数正常。增强CT扫描显示股总动脉动脉瘤,无感染特征。他的动脉瘤被切除,并用涤纶人工血管进行修复。从动脉瘤组织中培养出单核细胞增生李斯特菌,随后开始给予适当的抗生素治疗。还用人造血管动脉瘤的静脉旁路替代了人工血管。
单核细胞增生李斯特菌是真菌性动脉瘤的罕见病因,文献报道不足40例。免疫抑制是李斯特菌感染的公认危险因素。免疫功能低下的患者可能不会表现出与真菌性动脉瘤相关的典型临床或生化特征。人工血管感染与显著的死亡率相关,切除人工材料并进行静脉重建对于根除感染有良好效果。
本报告强调了在免疫功能低下患者中获取术中组织样本进行微生物学和组织病理学评估的重要性。这对于检测如单核细胞增生李斯特菌等罕见病原体很重要,因为需要针对性的抗生素治疗。对李斯特菌感染治疗不当可导致严重的侵袭性疾病。