Naaktgeboren N, Devroey P, Wisanto A, Traey E, Van Steirteghem A C
Radioimmunoassay and In Vitro Fertilization Laboratories, Academic Hospital and Medical School, Vrije Universiteit Brussel, Belgium.
Hum Reprod. 1986 Jan;1(1):9-14. doi: 10.1093/oxfordjournals.humrep.a136350.
Delayed implantation in cycles with ovarian stimulation and ovulation induction was observed in eight patients. Endocrinological evidence for ovulation during pregnancy is presented in three cases; in one of them the implantation was evidently rescued by a new active corpus luteum. All pregnancies had the following factors in common: (1) A delay in the detection of the first positive serum human chorionic gonadotrophin (HCG) by 4-5 days. (2) The corpus luteum was not rescued initially and menstruation started at low serum concentrations of 17 beta-oestradiol and progesterone between 12 to 18 days (13.8 +/- 1.9 days) after induction of ovulation. (3) Because of the negative HCG, menstrual bloodloss and low steroid hormone concentrations, a new ovarian stimulation was started and continued for some days until pregnancy was detected. On the basis of the endocrine findings, three different forms of delayed implantation could be distinguished. Two of the eight pregnancies had a normal progression until full-term delivery, two developed into echographically-confirmed clinical pregnancies, but aborted at 9 and 11 weeks after the first menstrual period had started. The remaining four ended with a preclinical abortion between 7 and 8 weeks.
在8例接受卵巢刺激和诱导排卵周期的患者中观察到着床延迟。3例患者出现孕期排卵的内分泌学证据；其中1例患者的着床明显是由新形成的活性黄体挽救的。所有妊娠均有以下共同因素：（1）首次血清人绒毛膜促性腺激素（HCG）阳性检测延迟4 - 5天。（2）最初黄体未得到挽救，在诱导排卵后12至18天（13.8±1.9天），当血清17β-雌二醇和孕酮浓度较低时月经开始。（3）由于HCG阴性、月经失血和类固醇激素浓度低，开始新一轮卵巢刺激并持续数天，直至检测到妊娠。根据内分泌学结果，可区分出三种不同形式的着床延迟。8例妊娠中有2例妊娠进展正常直至足月分娩，2例发展为超声确诊的临床妊娠，但在月经初潮开始后9周和11周流产。其余4例在7至8周时发生临床前流产。
