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一名肺癌患者出现急性冠状动脉综合征和复发性结肠炎，作为免疫相关不良事件。

Acute coronary syndrome and recurrent colitis as immune-related adverse events in a lung cancer patient.

作者信息

Cancela-Díez Bárbara, Gómez-De Rueda Félix, Antolinos Pérez María J, Jiménez-Morales Alberto, López-Hidalgo Javier L

机构信息

Pharmacy Unit, Universitary Hospital Virgen de las Nieves, Granada, Spain.

Pharmacy Unit, Universitary Hospital of Jaén, Jaén, Spain.

出版信息

J Oncol Pharm Pract. 2020 Jan;26(1):252-255. doi: 10.1177/1078155219865596. Epub 2019 Aug 5.

DOI:10.1177/1078155219865596
PMID:31382863
Abstract

Immune checkpoint inhibitors have become a target for pharmacological research in lung cancer. Immune-related adverse events (irAEs) such as pneumonitis, colitis, hepatitis and endocrinopathies have been well characterized in immune checkpoint inhibitors, but coronary toxicities, like acute coronary syndrome, are poorly described. Herein, we report a possible acute coronary syndrome as immune-related adverse event in a lung cancer patient.

摘要

免疫检查点抑制剂已成为肺癌药理学研究的一个靶点。免疫相关不良事件（irAEs），如肺炎、结肠炎、肝炎和内分泌病，在免疫检查点抑制剂中已有充分描述，但冠状动脉毒性，如急性冠状动脉综合征，却鲜有报道。在此，我们报告一例肺癌患者可能发生的急性冠状动脉综合征作为免疫相关不良事件。

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