视神经脊髓炎谱系疾病患者血清 IL-36β 和 IL-36γ 水平升高：与疾病活动度相关。
Increased serum IL-36β and IL-36γ levels in patients with neuromyelitis optica spectrum disorders: association with disease activity.
机构信息
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, No 154 Anshan Road, Heping District, Tianjin, 300052, China.
Department of Neurology, Tianjin TEDA Hospital, No 65 The Third Road, Tianjin Economic Technological Development Area, Tianjin, 300457, China.
出版信息
BMC Neurol. 2019 Aug 5;19(1):185. doi: 10.1186/s12883-019-1415-2.
BACKGROUND
Interleukin 36 (IL-36) cytokines belong to the IL-1 family and play an important role in some autoimmune diseases. However, the relationship between IL-36 and neuromyelitis optica spectrum disorders (NMOSD) remains unclear.
METHODS
We determined serum IL-36α, IL-36β and IL-36γ levels and assessed correlations with clinical characteristics in 50 NMOSD patients and 30 healthy controls (HC).
RESULTS
The concentrations of serum IL-36β and IL-36γ were significantly higher in patients with NMOSD than in HCs and decreased during remission. Serum IL-36β levels were positively correlated with the annual relapse rate (ARR), spinal cord lesion length and Expanded Disability Status Scale (EDSS) scores.
CONCLUSIONS
Serum IL-36β and IL-36γ levels were related to disease activity in NMOSD patients and may be important biomarkers of NMOSD.
背景
白细胞介素 36（IL-36）细胞因子属于白细胞介素 1 家族，在某些自身免疫性疾病中发挥重要作用。然而，IL-36 与视神经脊髓炎谱系疾病（NMOSD）之间的关系尚不清楚。
方法
我们测定了 50 例 NMOSD 患者和 30 例健康对照者（HC）的血清 IL-36α、IL-36β 和 IL-36γ 水平，并评估了它们与临床特征的相关性。
结果
NMOSD 患者的血清 IL-36β 和 IL-36γ 浓度明显高于 HC，且在缓解期下降。血清 IL-36β 水平与年复发率（ARR）、脊髓病变长度和扩展残疾状况量表（EDSS）评分呈正相关。
结论
血清 IL-36β 和 IL-36γ 水平与 NMOSD 患者的疾病活动度有关，可能是 NMOSD 的重要生物标志物。
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