Department of Laboratory Medicine, Chengdu Eighth People's Hospital (Geriatric Hospital of Chengdu Medical College), Chengdu, 610000, Sichuan, China.
Urology Department, Huili People's Hospital, Huili615100, Guangyuan, Sichuan, China.
Inflammopharmacology. 2024 Oct;32(5):2681-2694. doi: 10.1007/s10787-024-01534-8. Epub 2024 Aug 10.
Alzheimer's disease (AD) is a progressive and irreversible neurological condition that occurs with age and poses a significant global public health concern, is distinguished by the degeneration of neurons and synapses in various regions of the brain. While the exact processes behind the neurodegeneration in AD are not completely known, it is now acknowledged that inflammation may have a significant impact on the beginning and advancement of AD neurodegeneration. The severity of many neurological illnesses can be influenced by the equilibrium between pro-inflammatory and anti-inflammatory mediators. The IL-1 family of cytokines is linked to innate immune responses, which are present in both acute inflammation and chronic inflammatory diseases. Research on the role of the IL-1 family in chronic neurological disease has been concentrated on AD. In this context, there is indirect evidence suggesting its involvement in the development of the disease. This review aims to provide a summary of the contribution of every IL-1 family member in AD pathogenesis, current immunotherapies in AD disease, and present treatment possibilities for either targeting or boosting these cytokines.
阿尔茨海默病（AD）是一种随着年龄增长而发生的进行性和不可逆转的神经疾病，是一个重大的全球公共卫生关注点，其特征是大脑各个区域的神经元和突触退化。虽然 AD 中神经退行性变的确切过程尚不完全清楚，但现在已经认识到炎症可能对 AD 神经退行性变的开始和进展有重大影响。许多神经疾病的严重程度可以受到促炎和抗炎介质之间的平衡的影响。白细胞介素-1 家族细胞因子与先天免疫反应有关，先天免疫反应存在于急性炎症和慢性炎症性疾病中。关于白细胞介素-1 家族在慢性神经疾病中的作用的研究主要集中在 AD 上。在这种情况下，有间接证据表明其参与了疾病的发展。本综述旨在总结白细胞介素-1 家族每个成员在 AD 发病机制中的作用、AD 疾病中的当前免疫疗法，以及针对或增强这些细胞因子的现有治疗可能性。
