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兽医矫形外科学中的细菌性骨髓炎:多物种的病理生理学、临床表现和治疗进展。

Bacterial osteomyelitis in veterinary orthopaedics: Pathophysiology, clinical presentation and advances in treatment across multiple species.

机构信息

AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos, Switzerland.

AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos, Switzerland.

出版信息

Vet J. 2019 Aug;250:44-54. doi: 10.1016/j.tvjl.2019.06.003. Epub 2019 Jun 25.

Abstract

Bacterial osteomyelitis in veterinary patients can be challenging to diagnose and treat, given limited therapeutic options and reported success rates. Osteomyelitis is frequently associated with surgical implant devices, including those required to optimise stability and healing of fractures. However, management of osteomyelitis sometimes necessitates the removal of these surgical implant devices in order to eradicate infection or limit implant-related osteolysis. The goal of this article is to provide a general and species-specific review of bacterial osteomyelitis in a selection of domestic veterinary species, including cats, dogs, horses, cattle and camelids, with a focus on classification, clinical presentation, aetiologic agents, and common therapeutic interventions reported in the literature. New treatment options emerging from research and human medicine will be also discussed, as they also apply to current or future care of veterinary patients with osteomyelitis.

摘要

兽医患者的细菌性骨髓炎的诊断和治疗具有挑战性,因为治疗选择有限,且报告的成功率也有限。骨髓炎常与外科植入设备相关,包括那些优化骨折稳定性和愈合所需的设备。然而,骨髓炎的治疗有时需要移除这些外科植入设备,以消除感染或限制与植入物相关的骨溶解。本文的目的是对一些常见的家养宠物物种(包括猫、狗、马、牛和骆驼)中的细菌性骨髓炎进行一般的和特定物种的综述,重点介绍分类、临床表现、病因和文献中报道的常见治疗干预措施。本文还将讨论从研究和人类医学中出现的新的治疗选择,因为它们也适用于目前或未来兽医骨髓炎患者的治疗。

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